Can Cannabis Replace Opioids for Chronic Pain? A New Review Maps What We Knowโ€”and What Remains Uncertain

Clinical evidence has shown that cannabinoids can significantly reduce the intensity of chronic pain, particularly in cases of neuropathy, multiple sclerosis, arthritis, and other painful conditions that are unresponsive to conventional treatments. However, the full integration of medical cannabis into clinical practice faces significant obstacles, including the need for standardized dosing, long-term safety data, and regulatory frameworks.

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Cannabinoid Chewing Gum: Promising Concept, Weak Evidence

There has only been one published placebo-controlled trial investigating cannabinoid chewing gum as a drug delivery systemโ€ฆ both CBD and placebo reduced pain slightly, but there was no significant difference between CBD and placebo on primary outcomes (mean difference in 30-min pain reduction: 0.1 on VAS, 95% CI: [โ€“0.3, 0.5], p = 0.61).

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