If you use CBD products, understanding the entourage effect helps explain why full-spectrum formulations may offer greater therapeutic benefit than isolated CBD alone. An overview of the entourage effect explains how CBD works synergistically with other cannabinoids, terpenes, and flavonoids found naturally in full-spectrum hemp products to produce enhanced therapeutic outcomes compared to isolated CBD alone. The concept is supported by preclinical and emerging clinical data showing that combinations of non-psychotropic cannabinoids such as CBG, CBN, and CBDV amplify anti-inflammatory, anxiolytic, and analgesic effects.
The Munchies’ Are Real and Could Benefit Those with No Appetite
This Pullman-based study using real cannabis—not synthetic THC—provides the most realistic evidence yet that cannabis appetite effects can be translated into treatments for seriously ill patients. WSU’s official press release on the PNAS munchies study. Prof.
First Human Clinical Trial: CBG Reduces Anxiety and Stress Without Intoxication
If Texas—one of America’s most conservative states and a major hemp producer—signals voter support for legalization, it could dramatically accelerate federal cannabis reform that affects your access to products. In one of the first double-blind, placebo-controlled clinical trials of isolated CBG in humans, a 20mg oral dose of hemp-derived cannabigerol produced statistically significant reductions in subjective anxiety and stress, along with improved verbal memory, without intoxication, cognitive slowing, or motor impairment. The study of 34 healthy adults suggests CBG may influence stress and anxiety pathways without producing typical ‘drug effects.’ Researchers emphasize preliminary nature and need for replication.