WHY IT MATTERS: For parents and adolescents, this research reinforces that cannabis is not a low-risk substance during the teenage years, and decisions about use should be made with full awareness of the potential for lasting mental health consequences. CLINICAL OVERVIEW: Research continues to build a concerning picture around adolescent cannabis use and its association with elevated risk for psychiatric conditions, including psychosis, depression, and anxiety disorders. The developing brain, particularly during the teenage years, appears to be especially vulnerable to the neurochemical disruptions that cannabinoids can produce, with THC’s interaction with the endocannabinoid system potentially altering normal neurodevelopmental trajectories.