WHY IT MATTERS: If you use cannabis for anxiety, your results may be significantly shaped by your sleep habits, alcohol intake, and other lifestyle factors, not cannabis alone. CLINICAL OVERVIEW: Research examining cannabis use alongside other substances and lifestyle factors in medical contexts adds important nuance to how clinicians should approach anxiety management. Understanding the interplay between cannabis, alcohol, caffeine, exercise, sleep, and other variables helps explain why patients with anxiety report such variable outcomes with cannabis-based therapies.