WHY IT MATTERS: Patients using cannabis to manage anxiety or depression should be aware that without proper medical guidance on strain selection, THC-to-CBD ratios, and dosing, cannabis may be worsening the very symptoms they are trying to treat. CLINICAL OVERVIEW: Research from Canada is highlighting a parallel rise in cannabis use alongside increasing rates of anxiety and depression, raising important questions about the direction of causality and the role cannabis may be playing in mental health outcomes. The relationship between cannabis and mood disorders is complex, as individuals may be turning to cannabis to self-manage psychological distress while the substance itself, particularly high-THC products, can worsen anxiety and depressive symptoms over time.