Previous research has extensively demonstrated the abilities of cannabidiol (CBD) and tetrahydrocannabinol (THC), two main cannabinoids derived from the plant cannabis, to regulate the proliferation, migration, and differentiation of stem cells. For...
An Analysis of Over-the-Counter Cannabidiol Products in the United Kingdom
Cannabidiol (CBD), one of the major constituents of the plant cannabis, has received increasing interest in the United Kingdom in recent years for valid reasons. Research has proven its broad range of...
Use of Dronabinol Improves Appetite and Reverses Weight Loss in HIV/AIDS-Infected Patients
HIV wasting syndrome is defined as the involuntary loss of more than 10% of baseline body weight and is associated with chronic diarrhea, weakness, or fever. This common complication of HIV has...
Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
Melanoma is a highly metastatic skin cancer with increasing incidence and mortality rate worldwide. In 2018 alone, approximately 280,000 new cases and 61,000 deaths associated with melanoma were reported in 46 countries....
Drugs inhibiting cannabinoid receptor type-1 can reduce obesity-associated steatohepatitis
Cannabinoid receptor type 1 antagonist inhibits progression of obesityโassociated nonalcoholic steatohepatitis in a mouse model by remodulating immune system disturbances In Summary: Steatohepatitis, a condition often associated with type 2 diabetes and...
A promising cure for PTSD: Cannabis-based medicine suppresses aversive memory and eases anxiety
Effects of ฮ9-tetrahydrocannabinol on aversive memories and anxiety: a review from human studies In Summary: โ Post traumatic stress disorder (PTSD) is a mental disorder that arises after a person experiences or...
Cannabidiol: Attenuation of behavioral and cognitive schizophrenia symptoms leads to potential clinical applications
Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors In Summary Although cannabidiol (CBD), a major constituent of the plant cannabis, is known...
The wide distribution of cannabinoid receptors in the gastrointestinal tract suggests cannabinoids like CBD can relieve GI pain
Localization of cannabinoid and cannabinoid related receptors in the cat gastrointestinal tract โIn Summary Cannabidiol (CBD) is a component of the plant cannabis with great potential for medical applications because of its...
Neurological and neurodegenerative conditions, physical activities, and the endocannabinoid system โ how might all these be linked?
Can physical activity support the endocannabinoid system in the preventive and therapeutic approach to neurological disorders? In Summary The endocannabinoid signaling system (ECS) of the body includes naturally produced chemicals called cannabinoids,...
Activation of a cannabinoid receptor represents a promising therapeutic strategy for Parkinson’s Disease
Activation of CB2R with AM1241 ameliorates neurodegeneration via the Xist/miR-133b-3p/Pitx3 axis โIn Summary Schematic representation showing the proposed mechanism by which the CBR2 agonist AM1241 exerts neuroprotective effects through the Xist/ miR-133b-3p/Pitx3...