WHY IT MATTERS: Patients using cannabis therapeutically for appetite stimulation can now have greater confidence that the effect is rooted in measurable brain biology, not just anecdote, which may help guide more precise dosing conversations with their physicians. CLINICAL OVERVIEW: Cannabis-induced hyperphagia, colloquially known as “the munchies,” has long been observed clinically but its precise neurological underpinnings in humans have remained incompletely characterized. Emerging research points to cannabis activating reward-related brain circuitry, particularly pathways involving endocannabinoid signaling that amplify the hedonic and motivational aspects of eating.