WHY IT MATTERS: Patients who use cannabis recreationally or medicinally should understand that high-dose THC can temporarily impair judgment and increase vulnerability to social influence, particularly in unfamiliar settings or with strangers. CLINICAL OVERVIEW: Cannabis influences judgment and decision-making through its effects on the prefrontal cortex, where THC disrupts the normal signaling of the endocannabinoid system and impairs executive function, working memory, and risk assessment. These cognitive effects are dose-dependent and highly variable based on individual tolerance, cannabinoid ratios, and consumption patterns, meaning that susceptibility to poor judgment or social manipulation is not uniform across all users.