WHY IT MATTERS: Patients considering CBD products marketed for immune support should understand that while the endocannabinoid system does play a role in immune regulation, no CBD product has FDA approval for this indication, and product quality varies enormously across the unregulated market. CLINICAL OVERVIEW: The endocannabinoid system is a legitimate physiological network involved in regulating inflammation, stress responses, sleep architecture, and broader homeostatic balance, making it a plausible target for cannabinoid-based interventions. CBD interacts with this system through multiple receptor pathways, including CB1, CB2, and non-cannabinoid receptors such as TRPV1 and PPARgamma, which may help explain its proposed effects on immune modulation and stress resilience.