WHY IT MATTERS: If oral thin film cannabinoid delivery becomes clinically available, patients who struggle with inconsistent edible absorption or who cannot inhale may gain access to a faster-acting, more precisely dosed alternative. CLINICAL OVERVIEW: Oral thin film delivery systems for cannabinoids represent an evolving area of drug delivery research that could address some of the longstanding challenges in cannabis medicine, including inconsistent absorption, delayed onset, and difficulty achieving precise dosing. From a clinical perspective, sublingual and buccal delivery methods bypass first-pass hepatic metabolism, potentially offering more predictable pharmacokinetics compared to traditional edibles while providing a smoke-free alternative for patients who need rapid onset without inhalation.
IGC Pharma Adds Visionary Investigators Network as Clinical Site to Phase 2 CALMA Trial
WHY IT MATTERS: If you or a loved one is living with Alzheimer’s-related agitation, the expansion of this clinical trial means more opportunities to access investigational cannabinoid therapy and brings us closer to having FDA-reviewed evidence for cannabis-based treatment options in dementia care. CLINICAL OVERVIEW: The expansion of clinical trial sites for IGC Pharma’s Phase 2 CALMA trial investigating cannabinoid-based therapy for Alzheimer’s-associated agitation represents a meaningful step in building the evidence base for cannabis medicine in neurodegenerative disease. Alzheimer’s-related behavioral symptoms like agitation and aggression are notoriously difficult to manage with conventional medications, and cannabinoid therapies have shown early promise in addressing neuroinflammation and behavioral dysregulation through endocannabinoid system modulation.
DOJ Suggests ‘Frail and Elderly Grandmother’ Who Uses Medical Marijuana Could Face Armed Federal Agents
Ohio’s ability to identify and recall unsafe THC gummies proves that legal, regulated markets protect consumers in ways that unregulated black markets never can. Marijuana Moment reports on a DOJ filing suggesting that even a ‘frail and elderly grandmother’ who uses medical marijuana could theoretically face enforcement by armed federal agents under current law. The argument arose in litigation over the intersection of cannabis use and firearms rights under the Second Amendment.
Study Challenges Negative Cannabis Stereotypes, Claiming Link to Brain Benefits
Researchers confirmed that cannabis universally increases appetite regardless of your body type, gender, or how recently you ate—knowledge that could help develop better treatments for patients who can’t eat due to illness. Researchers at the University of Colorado Anschutz Medical Campus analyzed cannabis usage, brain scans, and cognitive test results for over 26,000 adults ages 40-77 using UK Biobank data. Moderate lifetime cannabis users showed larger volumes in brain regions rich in CB1 receptors—areas involved in memory, information processing, and emotion regulation.