WHY IT MATTERS: If you are a current or prospective cannabis patient, understanding your personal risk factors for dependence helps you and your physician build a safer, more individualized treatment plan with appropriate monitoring. CLINICAL OVERVIEW: Understanding the risk profile for cannabis dependence is a critical clinical question that helps physicians identify which adult patients can use cannabis therapeutically with lower likelihood of developing problematic use patterns. Factors such as age of initiation, mental health history, frequency of use, genetic predisposition, and the presence of other substance use disorders all contribute to a patient’s overall risk profile.