A large study found that moderate cannabis use in adults over 40 was linked to larger brain volumes and better cognitive function, though experts caution more research is needed before drawing conclusions. A landmark longitudinal study published in JAMA Health Forum followed 463,396 adolescents ages 13-17 through age 26. Past-year cannabis use during adolescence was associated with a doubled risk of developing psychotic and bipolar disorders, plus elevated risks for depression and anxiety.
Satiety Bypass: How Cannabis Overrides the Brain’s ‘I’m Full’ Signal
A massive study tracking over 460,000 teens found that cannabis use during adolescence doubled the risk of psychotic and bipolar disorders, underscoring why age restrictions and youth prevention are critical. Neuroscience News deep-dive into the WSU/Calgary PNAS study on cannabis-induced appetite. THC activates CB1 receptors in the hypothalamus to override natural satiety signals, creating a feeling of starvation even in recently fed subjects.
Adolescent Cannabis Use and Psychosis Risk: What This Cohort Study Shows and What It Does Not
A clinician-guided review of a large cohort study examining adolescent past-year cannabis use and subsequent psychiatric diagnoses, including psychosis and bipolar disorder. This article explains what the study measures, what it does not measure, and why causality cannot be assumed despite meaningful association signals.
More Research on Adolescent Cannabis Use and Mental Disorders
The persistence of the association between adolescent cannabis use and common mental disorders into young adulthood In Summary Further examination of chronic cannabis use in adolescents correlates with a higher prevalence of...