Clinical Takeaway Research suggests that standard cannabis prevention messaging often fails teens because it does not account for the wide range of beliefs young people hold about cannabis use. This study tested...
Endocannabinoid System: Cannabis, Pregnancy & Cytokines
Clinical Takeaway Cannabis use during pregnancy is associated with measurable suppression of maternal immune signaling proteins called cytokines, which play a critical role in protecting both mother and developing fetus. This immune...
`Cannabis-Induced Psychosis and Schizophrenia Risk: Key Evidence`
Clinical Takeaway A significant portion of patients diagnosed with cannabis-induced psychosis go on to develop schizophrenia spectrum or bipolar disorder, making early identification and close psychiatric follow-up critical. Clinicians should not assume...
Cannabinoid Formulations for Anxiety and Tourette Syndrome
Clinical Takeaway Cannabinoid formulations, particularly CBD-containing products, show measurable reductions in anxiety symptoms across multiple study designs, though effect sizes and optimal dosing remain inconsistent across trials. Evidence for Tourette syndrome is...
Endocannabinoid System Research: Cannabis in HIV Care
Clinical Takeaway A digital therapeutic tailored specifically for people living with HIV showed strong feasibility and acceptability as a smoking cessation tool, suggesting this population can be effectively reached through app-based interventions....
Cannabidiol for Lennox-Gastaut: Cannabinoid Clinical Trials
Clinical Takeaway Plant-derived cannabidiol (CBD) oral solution produced meaningful reductions in drop seizures in patients with Lennox-Gastaut syndrome at thresholds below the traditional 50% benchmark used in clinical trials. Caregiver-reported outcomes aligned...
Endocannabinoid System Research: Cannabis for Endometriosis
Clinical Takeaway Researchers attempted a three-armed randomized controlled trial comparing inhaled THC-dominant cannabis, an oral cannabis oil, and placebo for endometriosis pain, but encountered significant feasibility challenges that limited their ability to...
Cannabinoid Clinical Trials: CBD Gel Safety in Fragile X
Clinical Takeaway Transdermal cannabidiol gel (ZYN002) has been studied in children and adolescents with Fragile X syndrome through an open-label extension trial focused on long-term safety and tolerability. Early interim data suggest...
`Cannabinoid Clinical Trials: CBD, WADA, and Urine Testing`
Clinical Takeaway Athletes using broad-spectrum CBD supplements risk testing positive for WADA-prohibited cannabinoids such as CBG and CBDV, even when the CBD itself is legal. This study found that 10 weeks of...
Cannabinoid Clinical Trials: CBD, Psychosis Risk & Brain
Clinical Takeaway In a small study of individuals at clinical high risk for psychosis, a single dose of CBD was found to influence the relationship between hippocampal glutamate levels and prefrontal brain...