Clinical Takeaway Across randomized clinical trials, cannabis derivatives and their analogs showed promising early signals for improving core and associated symptoms of autism spectrum disorder, including social communication and behavioral challenges. The...
Endocannabinoid System & Teen Mental Health: Clinical Evidence
Clinical Takeaway Adolescents with higher levels of depression and anxiety symptoms were more likely to initiate and use cannabis more frequently over the following 18 months, supporting the idea that young people...
Adolescent Cannabis Use: Mental Health Risks Examined
Clinical Takeaway Adolescent cannabis use is associated with significantly increased risk of developing psychotic, bipolar, depressive, and anxiety disorders in adolescence and young adulthood, based on large-scale longitudinal population data. These findings...
Endocannabinoid System Research: Trauma, Sleep & Cannabis Use
Clinical Takeaway Insomnia symptoms present before a traumatic event may increase the risk of alcohol and cannabis use in the weeks and months that follow, potentially through their influence on early posttraumatic...
`Cannabinoid Clinical Trials: CBD Cortical Excitability Study`
Clinical Takeaway In a controlled crossover trial of healthy males, neither a low (30 mg) nor a high (700 mg) single dose of CBD produced measurable changes in cortical excitability compared to...
Cannabinoid Clinical Trials: Sleep, EEG & Insomnia RCT
Clinical Takeaway In this small pilot trial of 20 adults with diagnosed insomnia disorder, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared...
`Endocannabinoid System & Adolescent Health: 15-Year REAL 2.0 Study`
Clinical Takeaway A 15-year Canadian cohort study tracked adolescents into early adulthood to examine how body image concerns and disordered eating in youth predict later eating disorders, mental health conditions, and substance...
`Endocannabinoid System Research: Cannabis for PTSD + SUD`
Clinical Takeaway Trauma-focused therapies remain effective for PTSD even when patients are actively using cannabis, including those with co-occurring substance use disorders. Clinicians should not withhold or delay evidence-based PTSD treatment due...
endocannabinoid system clinical research: mobile mental health
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-developed with university students, to address mental health and substance use during the high-risk college transition period. Digital tools like this...
`Endocannabinoid System Research: Athlete Mental Health`
Clinical Takeaway Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and cognitive concerns after their careers end, with factors like concussion history, abrupt retirement, and loss...