CED Clinical Relevance #50Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic CancerCbdOncologyBiomarkersClinical Study JournalJournal of clinical medicineStudy TypeClinical StudyPopulationHuman participants Why This MattersRenal cell carcinoma remains challenging...
Advances in the Understanding of Akt Signaling in Cancers and the Potential of Inhibiting Akt-Driven Tumors Using Small Molecule Inhibitors: An Overview.
The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is a central regulator of cellular metabolism, survival, and proliferation and is frequently d…
A behavioral economics substance-free activity session (SFAS) approach to reducing substance use: Narrative review and intervention manual.
Standard brief alcohol and drug use interventions focus on motivating reductions in use and associated harms and have shown reliable reductions in these outc…
Targeting Amyloid Beta Aggregation and Neuroinflammation in Alzheimer’s Disease: Advances and Future Directions.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly. Among the diverse pathological fea…
Unraveling Lennox-Gastaut Syndrome: From Molecular Pathogenesis to Precision Diagnosis and Targeted Therapy Evolving Therapeutic Strategies.
Lennox-Gastaut syndrome (LGS) is a rare and severe developmental and epileptic encephalopathy characterized by multiple drug-resistant seizure types, mandato…
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment.
Epigenetic clocks are commonly used aging biomarkers based on DNA methylation that predict long-term morbidity and mortality risk. Increased cellular senesce…
Precision prediction of posttraumatic stress disorder symptom surges: A pilot study integrating real-time daily data with supervised learning.
The application of machine learning algorithms to daily diary data represents a valuable tool for improving dynamic prediction of posttraumatic stress disord…
Factors associated with using disposable versus non-disposable electronic cigarettes among adults in the U.S. and Israel: a cross-sectional study with policy implications.
In recent years, there has been a rapid increase in disposable electronic cigarette (e-cigarette) use. Several countries have banned or are considering banni…
Cannabinoids Appear Generally Safe in Adults Over 50, But Evidence Is Limited and Heterogeneous
Although cannabinoid-based medications were generally safe and acceptable to adults aged over 50 years, these estimates are limited by the lack of a control condition and considerable heterogeneity. Nevertheless, they complement and are consistent with comparable evidence from randomised controlled trials.
Medical Cannabis in Older Adults: Promising Interest, Thin Evidence
Evidence of efficacy for relief of an array of symptoms is overall scanty, and almost all study participants are aged < 60 years. The risk of known and potential adverse effects is considerable, with concerns for cognitive, cardiovascular and gait and stability effects in older adults.