Clinical Takeaway Many people with endometriosis already use cannabis for symptom relief, but rigorous clinical evidence for its effectiveness has been lacking. This Australian trial attempted to evaluate the safety and feasibility...
`Cannabinoid Clinical Trials: CBD and WADA Drug Testing`
Clinical Takeaway Daily use of a broad-spectrum CBD supplement containing trace amounts of other cannabinoids can result in urine concentrations of WADA-prohibited substances such as CBG and CBDV, potentially placing athletes at...
Cannabinoid Clinical Trials: CBD, Psychosis & Brain Function
Clinical Takeaway In a study of individuals at clinical high risk for psychosis, a single dose of CBD influenced the relationship between hippocampal glutamate levels and prefrontal brain activity during verbal memory...
Endocannabinoid System Research: Cannabis Use in Pregnancy
Clinical Takeaway Children born to mothers who used cannabis during pregnancy showed a modestly elevated risk of autism spectrum disorder and a smaller increased risk of ADHD based on pooled data from...
Cannabinoids for Autism: Clinical Evidence & ASD Research
Clinical Takeaway Several randomized clinical trials have examined cannabis derivatives, including CBD-rich preparations, for core and associated symptoms of autism spectrum disorder, with findings suggesting potential benefits for behavioral challenges, anxiety, and...
Endocannabinoid System & Teen Anxiety: Clinical Evidence
Clinical Takeaway Adolescents with depression and anxiety symptoms show increased likelihood of initiating and escalating cannabis use over time, suggesting internalising disorders may drive substance use as a coping mechanism. Clinicians working...
Adolescent Cannabis Use and Psychotic Disorder Risk
Clinical Takeaway Adolescent cannabis use is associated with increased risk of developing psychotic, bipolar, depressive, and anxiety disorders in adolescence and young adulthood, based on large population-level longitudinal data tracking clinically diagnosed...
Endocannabinoid System & Trauma Sleep Research Insights
Clinical Takeaway Insomnia symptoms present before a traumatic event may increase the risk of developing problematic alcohol or cannabis use in the weeks and months following trauma exposure. This relationship appears to...
Endocannabinoid System Research: Cannabis and PTSD Care
Clinical Takeaway Trauma-focused treatments remain effective for PTSD even when patients report cannabis use alongside co-occurring substance use disorders. Cannabis use does not appear to undermine the clinical benefit of evidence-based, trauma-focused...
Endocannabinoid System: Cannabis for Chronic Pain Evidence
Clinical Takeaway Cannabinoids, particularly products with measurable THC content, show modest but consistent evidence for reducing chronic pain compared to placebo in randomized controlled trials, though the overall certainty of evidence remains...