CED Clinical Relevance #50Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic Tourette SyndromeTicsNeurological DisordersMedical CannabisPatient Education JournalEuropean child & adolescent psychiatryStudy TypeClinical StudyPopulationHuman participants Why This MattersMedia...
Nonswallowed Kratom-Derived Products: Unlawful Dietary Supplements That Endanger Public Health.
The Dietary Supplement Health and Education Act of 1994 specified that dietary supplements must be swallowed. In this study, we investigated whether kratom-d…
Concomitant activation of D
Methylphenidate is commonly prescribed to manage symptoms of attention-deficit/hyperactivity disorder (ADHD), but like other stimulants it has limited effect…
Serine Hydrolase Targets of a Sarin Surrogate Anticholinesterase and Oxime Mediated Reactivation in Rat Brain.
While acetylcholinesterase (AChE) is the primary inhibitory target for organophosphate (OP) insecticides and chemical warfare nerve agents, research supports…
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990-2023: a Global Burden of Disease study.
Chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD) and pulmonary s…
GPR3 in neuro-metabolic-immune-reproductive nexus – a potential therapeutic target for Multi-System diseases.
GPR3(G-protein-coupled receptor 3), an orphan G-protein-coupled receptor (GPCR) with constitutive Gs activity, is expressed in the brain, liver, ovary, and o…
Epigenetic Dysregulation in Neurodegeneration: The Role of Histone Deacetylases and Emerging Inhibitor Strategies.
Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) are characterized by complex pathologies…
Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids.
Neurocutaneous dysesthesia (ND) is characterized by abnormal skin sensations such as pruritus or burning without an underlying skin condition. It is caused b…
Annexin A2 Causes Motor Incoordination via Muscle-Cerebellum Axis in Sarcopenia.
Sarcopenia is a prevalent age-related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequence…
Prevalence and factors associated with polypharmacy among people with multiple sclerosis (PwMS) receiving outpatient rehabilitation: A cross-sectional study.
Over 2.8 million people are living with multiple sclerosis (MS), many with comorbidities requiring pharmacologic intervention. This can lead to increased med…