Clinical Takeaway In a controlled crossover trial of healthy males, CBD at both low and high doses did not directly reduce cortical excitability compared to placebo, suggesting its anti-seizure benefits may depend...
Cannabinoid Clinical Trials: Cannabis for Insomnia EEG
Clinical Takeaway In this pilot trial of 20 adults with clinically diagnosed insomnia, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared to...
`Endocannabinoid System Research: Cannabis for Anxiety Care`
Clinical Takeaway Cannabis use was associated with daily reductions in anxiety, but the effects differed meaningfully depending on whether participants used flower or edible products and the cannabinoid composition (CBD, THC, or...
`Cannabidiol for Fibromyalgia: Clinical Trial Evidence`
Clinical Takeaway In this randomized, double-blind, placebo-controlled trial, CBD did not demonstrate superiority over placebo in reducing pain among patients with fibromyalgia. The findings add to a growing body of evidence suggesting...
`Cannabinoid Clinical Trials: PTSD and Substance Use Meta-Analysis`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments, and cannabis use does not appear to undermine treatment outcomes compared to...
Endocannabinoid System Clinical Research: 2024 RCT Review
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-developed with university students, to address mental health and substance use challenges during the college transition period. Digital tools like this...
Endocannabinoid System & Athlete Mental Health Research
Clinical Takeaway Retired professional athletes from high contact team sports face elevated rates of depression, anxiety, and other mental health challenges compared to the general population, with factors like concussion history, identity...
endocannabinoid system clinical research: CBD & Metabolism
Clinical Takeaway In this pilot study, short-term low-dose CBD supplementation did not produce measurable improvements in glucose tolerance, gut microbiome composition, or inflammation markers in sedentary adults with overweight or obesity. While...
Endocannabinoid System Research: Cannabinoids for Children
Clinical Takeaway Cannabinoids have been studied across a wide range of pediatric medical conditions, with the strongest and most consistent evidence supporting their use in treatment-resistant epilepsy. The available data suggest potential...
endocannabinoid system clinical research: Cannabis for Back Pain
Clinical Takeaway In this phase 3 trial of 820 adults with chronic low back pain, VER-01, a full-spectrum cannabis extract, was evaluated over a 12-week double-blind treatment period with up to 12...