Clinical Takeaway In this randomized, double-blind, placebo-controlled trial, CBD did not demonstrate superiority over placebo in reducing pain among patients with fibromyalgia. These findings suggest that, at the doses studied, CBD should...
`Cannabinoid Clinical Trials: PTSD and Substance Use`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments. Cannabis use does not appear to undermine the effectiveness of evidence-based PTSD...
Endocannabinoid System Research: Cannabis in Mental Health Care
Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-developed with university students, to address mental health and substance use challenges during the high-risk transition period of university attendance. Digital...
`Endocannabinoid System Research: Athlete Mental Health`
Clinical Takeaway Retired professional athletes from high contact team sports such as football, rugby, and hockey face elevated rates of depression, anxiety, and cognitive concerns compared to the general population. Key factors...
Cannabidiol & Glucose Tolerance: Clinical Evidence Review
Clinical Takeaway In this pilot study, short-term low-dose CBD supplementation did not measurably improve glucose tolerance or beneficially alter the gut microbiome in sedentary adults with overweight or obesity. While animal research...
Cannabinoids for Pediatric Care: Clinical Evidence Review
Clinical Takeaway Most of the available evidence on cannabinoid use in children comes from observational studies and surveys rather than controlled trials, limiting the strength of conclusions that can be drawn. The...
`Cannabinoid Clinical Trials: Cannabis for Chronic Back Pain`
Clinical Takeaway In this Phase 3 trial of 820 adults with chronic low back pain, a full-spectrum cannabis extract (VER-01) was evaluated over a 12-week blinded treatment period with extended follow-up reaching...
Cannabis and Inflammation: Clinical Mechanisms
How cannabinoids reduce inflammatory markers
Cannabinoid Clinical Trials: CBD & Cortical Excitability
Clinical Takeaway In this randomized controlled trial, CBD at both low (30 mg) and high (700 mg) single doses failed to directly reduce cortical excitability in healthy adults, suggesting its anti-seizure effects...
Cannabinoid Clinical Trials: EEG Sleep Insomnia RCT
Clinical Takeaway In this small pilot trial of 20 adults with diagnosed insomnia disorder, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared...