To assess the efficacy of cannabis for the treatment of acute migraine. Preclinical and retrospective studies suggest cannabinoids may be effective in migrai…
endocannabinoid system clinical research: CBD & psychosis
Clinical Takeaway In a study of individuals at clinical high risk for psychosis, a single dose of CBD influenced the relationship between hippocampal glutamate levels and prefrontal brain activity during verbal memory...
Topical Cannabis for AIMSS: Medical Cannabis Evidence
Clinical Takeaway In this randomized trial, topical cannabis balms were evaluated for feasibility and tolerability in postmenopausal breast cancer patients experiencing joint pain and stiffness from aromatase inhibitor therapy. The study found...
Cannabidiol Drug Interactions: Clinical Evidence Review
Clinical Takeaway CBD can interact with multiple drug classes commonly used in cancer care, particularly opioids, making careful medication review essential before starting CBD in patients on complex regimens. Clinicians should treat...
Maternal Cannabis & Autism/ADHD Risk: Clinical Evidence
Clinical Takeaway Children born to mothers who used cannabis during pregnancy showed a modestly elevated risk for autism spectrum disorder and a smaller increase in risk for ADHD, based on a meta-analysis...
Detection of ฮ9-Tetrahydrocannabinol Impairment Using Resting-State Functional Near-Infrared Spectroscopy: A Randomized Clinical Trial.
The primary psychoactive compound in cannabis, โ9-tetrahydrocannabinol (THC) induces intoxication and functional impairment, raising safety concerns in drivi…
Selective Personality-Targeted Intervention and the Escalation of Substance Use During Adolescence: A Secondary Analysis of A Cluster-Randomized Clinical Trial.
Substance use is a leading cause of burden of disease worldwide. Selective prevention programs can help reduce the development of problematic substance use a…
Cannabinoids for Autism: Clinical Evidence Reviewed
Clinical Takeaway CBD-based treatments, particularly cannabidiol-rich preparations, have shown preliminary benefits for certain autism-associated behaviors such as irritability, hyperactivity, and social communication challenges in some clinical trials. However, the current evidence base...
Cannabis-based medicines for chronic neuropathic pain in adults.
Estimates of the population prevalence of chronic pain with neuropathic components range from 6% to 10%. Current pharmacological treatments for neuropathic p…
Medical marijuana for management of cancer pain: a narrative review.
The increasing legalization of medical marijuana in the United States (US) has spurred ongoing interest in its clinical application for the management of can…