Clinical Takeaway In this pilot study, short-term low-dose CBD supplementation did not meaningfully change blood sugar regulation or gut bacterial composition in overweight or obese sedentary adults. While animal research has suggested...

Clinical Takeaway Current evidence on cannabinoids in pediatric patients spans a wide range of study types, with most data coming from observational research rather than controlled trials. The existing literature suggests both...

Clinical Takeaway In this phase 3 trial of 820 adults with chronic low back pain, the full-spectrum cannabis extract VER-01 was evaluated against placebo over 12 weeks with extended follow-up up to...

Cannabis use disorder occurs in approximately 1 in 10 regular users and as many as one-third of those who use daily, with persons with CUD having higher risks of poor mental health, psychoses and bronchitis.

Clinical Takeaway In a controlled trial of healthy males, neither a low (30 mg) nor a high (700 mg) single dose of CBD produced measurable changes in cortical excitability or sedation compared...

Clinical Takeaway In this pilot RCT of 20 adults with diagnosed insomnia, a single oral dose of 10 mg THC combined with 200 mg CBD reduced total sleep time compared to placebo,...

Clinical Takeaway Cannabis use was associated with daily reductions in anxiety, but the effects differed meaningfully depending on whether participants used flower or edible products and the cannabinoid composition (CBD, THC, or...

Clinical Takeaway In this randomized, double-blind, placebo-controlled trial, CBD did not demonstrate superiority over placebo in reducing pain among patients with fibromyalgia. These findings highlight the gap between widespread patient use of...

Clinical Takeaway People with PTSD and co-occurring substance use disorders who also use cannabis can still benefit meaningfully from trauma-focused treatments. Clinicians should not withhold or delay evidence-based PTSD care solely because...

Clinical Takeaway A randomized controlled trial tested the Minder mobile app, co-designed with university students, to address mental health and substance use concerns during a high-risk transitional period. The study evaluated whether...