Although incident off-label oral cannabinoid use was relatively low among all older Ontarian adults, this drug class was used with greater frequency and more often in potentially concerning ways among older adults with COPD.
Older Adults and Medical Cannabis: Promising Interest, Scarce Evidence
Evidence of efficacy for relief of an array of symptoms is overall scanty, and almost all study participants are aged < 60 years. The risk of known and potential adverse effects is considerable, with concerns for cognitive, cardiovascular and gait and stability effects in older adults.
Nearly Half of Older Cancer Survivors Reported Ever Using Cannabis — But Only 8% Discussed It With Their Doctor
Even within a state without a legal cannabis marketplace, older cancer survivors might commonly use cannabis to alleviate health concerns but [are] unlikely to discuss this with their providers.
Cannabidiol mitigates high-fat-diet-induced early-stage inflammation in two adipose tissue fat depots of Wistar rats.
Cannabidiol (CBD) has potential for treating obesity-induced inflammation; thus, we studied the influence of CBD on the accumulation of lipid precursors of i…
Five Distinct Patterns of Prescription Drug Misuse Sources Identified Among US Teens
Nonmedical users who obtained prescription drugs from multiple sources were more involved in substance use. In contrast, adolescent nonmedical users who used their own leftover prescriptions were less involved in substance use.
Older Adults on Prescribed Cannabis Report Well-Being Gains, But Study Cannot Rule Out Placebo or Natural Recovery
Older aged individuals experience considerable improvement in health and well-being when prescribed cannabis-based medicinal products — though these findings come from an observational registry without a comparator arm, meaning improvement cannot be attributed solely to the intervention.
Unregulated Substance Abuse and Systemic Inflammation Markers: A Review.
CED Clinical Relevance #55Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic InflammationSubstance UseBiomarkersPolysubstanceReview JournalHealthcare (Basel, Switzerland)Study TypeClinical StudyPopulationHuman participants Why This MattersThis review examines the relationship between...
Advertising Among Cannabidiol (CBD) Retailers in North Carolina: A Pilot Study.
Cannabidiol (CBD) is widely available to consumers who report using it for health-related purposes. However, little is known about the marketing of CBD. This…
A novel adverse outcome pathway in aluminum-induced male infertility: Oxidative stress-mediated endoplasmic reticulum stress and endocannabinoid system activation delineated by network toxicology and metabolomics.
Aluminum has been recognized as a reproductive toxin, yet the precise mechanisms by which embryonic exposure impairs male offspring development remain largel…
Lifestyle and Behavioral Enhancements of Sleep: A Review.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic SleepSleep HygieneCbt-ILifestyle MedicineBehavioral Interventions JournalAmerican journal of lifestyle medicineStudy TypeClinical StudyPopulationHuman participants Why This MattersSleep disorders...