Although CBMs in general are safe and acceptable in middle aged and older adults, one needs to be mindful of certain common dose-dependent side-effects of THC-containing CBMs.
Older Adults Using Prescribed Cannabis Report Well-Being Improvements, But Causal Claims Remain Unsupported
Older aged individuals experience considerable improvement in health and well-being when prescribed cannabis-based medicinal products—though this is an observational registry without a control group, so causality cannot be established.
A Geriatrics Practice Built a Medical Cannabis Clinic — Here Is What They Found
Drug utilization reviews revealed a mean of 4.6 interactions per patient. Common medications included CNS depressants (66.0%), pain medications (59.0%), and psychiatric medications (56.9%).
Citalopram Shows Modest Benefit for Dementia Agitation; Trazodone Linked to Higher Adverse Events
Among the antidepressant drugs included in this study, treatment with citalopram was probably the only optimal intervention, when considering the improvement from baseline to the end of the intervention, and there was not a statistically significant difference in safety when compared with a placebo treatment.
Cannabis Use Linked to Higher Blood Clot Risk in Older Trauma Patients
THC+ patients had significantly higher rates of TEC compared to THC- patients (3.0% vs. 1.7%; p=0.01). Rates of DVT (2.2% vs 0.6%, p<0.01) and PE (1.4% vs 0.4%, p<0.01) were higher in the THC+ group.
Cannabinoids Show Modest Promise for Cancer-Related Appetite Loss in Older Adults, but Evidence Remains Thin
Cannabinoids offer promise in enhancing the quality of life for older individuals with active neoplastic disease. However, to establish comprehensive guidelines, further research with larger sample sizes is essential.
Three Preliminary Studies on Cannabis, Social Isolation, and Dementia Offer Early Signals But No Firm Conclusions
Systematic studies of effectiveness and safety in older users of cannabinoids are needed given its increasing use. — NR-7 conclusions
Older Adults Report Pain, Sleep, and Mood Benefits from Medical Cannabis — But the Evidence Has Major Gaps
Among older adults, medical cannabis is used more often by women, with CBD-containing cannabis oils being the most commonly used. Users reported improved pain, sleep, and mood symptoms at follow-up — though without a control group, these self-reported changes cannot be causally attributed to cannabis.
Older Adults Using Cannabis for Sleep Rely More on THC and Use It More Frequently, Small Clinic Survey Finds
Patients using cannabis for sleep disturbance used it more frequently compared to those using it for other reasons (76% vs. 43% consumed cannabis daily/weekly, p=.01) and were more likely to report use of THC-containing products (62% vs. 32%, p<.01).
Cannabis Medicines Appear Broadly Tolerated in Adults Over 50, But Key Uncertainties Remain
Although cannabinoid-based medications were generally safe and acceptable to adults aged over 50 years, these estimates are limited by the lack of a control condition and considerable heterogeneity. Nevertheless, they complement and are consistent with comparable evidence from randomised controlled trials.