Aluminum has been recognized as a reproductive toxin, yet the precise mechanisms by which embryonic exposure impairs male offspring development remain largel…
Lifestyle and Behavioral Enhancements of Sleep: A Review.
CED Clinical Relevance #56Monitored Relevance Early-stage or contextual signal requiring further evidence before action. 🔬 Evidence Watch | CED Clinic SleepSleep HygieneCbt-ILifestyle MedicineBehavioral Interventions JournalAmerican journal of lifestyle medicineStudy TypeClinical StudyPopulationHuman participants Why This MattersSleep disorders...
Nationwide outcomes of cardiac surgery in patients with cannabis use disorder.
To characterize in-hospital morbidity and mortality in patients undergoing cardiovascular surgery with and without cannabis use disorder (CUD) using a nation…
Do Cannabis Users Require More Anesthesia During Third Molar Removal Under Intravenous General Anesthesia When Compared to Nonusers?
Cannabis users (CUs) may have higher intravenous general anesthetic (IVGA) requirements. It is unclear how cannabis exposure correlates with anesthetic requi…
Activation of Cannabinoid Receptor 1 Enhances Wound Healing by Promoting the Proliferative Phase.
The mechanisms underlying wound healing mediated by cannabinoid receptor 1 (CB1)-known for its neuromodulatory functions-remain incompletely understood. Ther…
Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction.
Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the d…
Management of Opioid Withdrawal Syndrome and Commencement of Opioid Dependence Treatment Following Chronic Use of a Vaping Product Containing Protonitazene: Case Report.
Nitazenes, benzimidazole synthetic potent opioid ฮผ-receptor agonists, have been implicated in increased risk for opioid toxicity. Subtypes of nitazenes, incl…
Cannabis-Based Spray Shown Feasible and Safe for Alzheimer’s Agitation in UK Care Homes
Despite significant COVID-19 pandemic-related challenges, administering nabiximols through oral mucosa to advanced Alzheimer’s patients with agitation demonstrated feasibility and safety. These findings support a larger confirmatory efficacy trial.
Older Adults on Cannabis and Interacting Drugs Face Elevated Intoxication Risk, Study Finds
The risk of drug-related intoxication was 2.61 (95% CI 1.42โ4.79) amongst 3,926 patients exposed to cannabis and DNTI compared to 12,223 controls, suggesting that prescribing practices for cannabis may not adequately consider the implications of concomitant interacting medications.
Cannabis Medicines Cause Dose-Dependent Side Effects in Older Adults, Meta-Analysis Finds
THC dose-dependently increased the incidence of dry mouth, dizziness/lightheadedness, mobility/balance/coordination difficulties, dissociative/thinking/perception problems and somnolence/drowsiness.