| Journal | medRxiv : the preprint server for health sciences |
| Study Type | Systematic Review |
| Population | Human participants |
With cannabis legalization expanding and nearly one in five tobacco users also using cannabis, clinicians need evidence-based guidance on how co-use affects smoking cessation success. This comprehensive review addresses a critical knowledge gap as we manage patients with dual substance use patterns.
This systematic review and meta-analysis examined 52 studies across observational, preclinical, and human experimental designs to understand cannabis co-use impacts on tobacco cessation and endocannabinoid system therapeutic potential. Meta-analysis of 18 observational studies involving over 229,000 participants found that cannabis use was associated with reduced tobacco cessation success rates. The review synthesized evidence from multiple study types to provide a translational perspective on endocannabinoid system modulation for tobacco use disorder, where current pharmacotherapies achieve less than 30% twelve-month abstinence rates.
“This confirms what I observe clinically – patients using both cannabis and tobacco face additional complexity in cessation efforts. While the endocannabinoid system remains an intriguing therapeutic target, the current evidence suggests cannabis co-use may complicate rather than facilitate tobacco cessation.”
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This study item was assembled from normalized source metadata and pipeline scoring.