Converging neurotrophic-immune signaling in autism spectrum disorder
This review examines the role of four interconnected signaling pathways in autism spectrum disorder. Among them, IGF-1 shows clinical trial support, while others remain preclinical or mechanistic.
Dietary Fiber and Glucagon-Like Peptide-1 Receptor Agonists in Obesity Managemen
GLP-1 receptor agonists and dietary fibers converge on the gut-brain axis, offering complementary benefits. This review examines their synergies and potential interactions in weight loss and maintenance.
Dysesthesia associated with GLP-1 agonist therapies- data-mining analysis
A study reveals that GLP-1 agonists like semaglutide are linked to significant signals for hyperesthesia, dysesthesia, and burning sensation. These reactions are dose-dependent and can recur upon rechallenge.
Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum
Sub-chronic cannabis smoke exposure alters inflammatory cytokines bidirectionally in younger and older mice, primarily impacting the hippocampus.
Efficacy and safety of GLP-1 receptor agonists in Parkinson’s disease- a systematic review
A recent study examines the use of GLP-1RAs in Parkinson's disease, finding no significant motor benefits but some improvement in quality of life.
Ethical Issues Related to the Use of GLP‐1 Receptor Agonists Such as Ozempic and Wegovy and Monjaro
GLP-1 receptor agonists offer significant health benefits but raise ethical concerns about long-term safety, access equity, and societal impacts.
GLP-1 agonists in addiction therapy – review
GLP-1 receptor agonists show promise in reducing alcohol consumption and cravings, as well as supporting nicotine abstinence. However, more research is needed for stimulant use disorders.
Safety of GLP-1 receptor agonists in body contouring surgery- a systematic review
A systematic review found a possible but fragile signal for increased wound dehiscence with GLP-1 RA use in body contouring. No other significant perioperative complications were observed.
SemaGBA- A System Dynamics Model of the Semaglutide-Responsive Gut-Brain Axis
The SemaGBA model simulates semaglutide's effects on metabolic and neural pathways, providing insights into its mechanisms of action.
Short-term effect of tirzepatide on serum calcitonin in adults with obesity
Tirzepatide treatment for 12 weeks resulted in a modest increase in serum calcitonin levels, remaining within normal ranges and showing no clinically relevant thyroid abnormalities.