#85 Research Authority
Peer-reviewed research curated for clinical relevance and evidence quality.
Recent research digest. 20 of 20 most recent studies from our monitored feeds.
Cannabis Use and Food Insecurity Risk Among U.S. Adults With And Without Children.
Chakraborty Rishika et al.
American journal of preventive medicine • 2026
# Clinical Summary This study found that cannabis use among young adults aged 18-34 in the United States was associated with increased risk of food insecurity, with notably stronger associations observed among parents compared to non-parents. The findings suggest that parental status significantly modifies the relationship between cannabis use and food insecurity, indicating that young parents who use cannabis may face particular vulnerability to household food shortages.
Recreational Cannabis Use During Human Pregnancy: Its Effects on the Placenta and Endocannabinoid System.
Harhangi Madhavi S et al.
International journal of molecular sciences • 2026
# Clinical Summary Cannabis use during pregnancy, particularly its active components THC and CBD, may interfere with the placental endocannabinoid system that normally regulates placental development and blood flow, raising concerns about fetal development. The increasing prevalence of recreational cannabis use in pregnant women coincides with legalization efforts, yet significant gaps remain in understanding how THC and CBD specifically affect placental function and fetal outcomes.
Using Alcohol and Sleep Sensors to Understand Blackout Risk in Young Adults’ Natural Settings (The Lights Out Study): Protocol for an Intensive Longitudinal Pilot Study.
Richards Veronica L et al.
JMIR research protocols • 2026
I cannot provide a summary of key findings because this document is a study protocol describing a planned research project, not a completed study with results. The abstract ends mid-sentence and does not contain any findings data. To summarize findings, I would need access to the results section of a completed study.
Clinical, physiological, imaging and molecular responses to cannabis smoking: the Canadian Users of Cannabis Smoke (CANUCK) study.
Leung Clarus et al.
The European respiratory journal • 2026
# Clinical Summary The CANUCK study found that cannabis smoking was associated with dose-dependent respiratory symptoms and airway changes, with higher exposure levels showing greater clinical and physiological effects on lung function. Advanced imaging and molecular analysis revealed specific patterns of airway epithelial dysfunction that correlated with cumulative cannabis use, suggesting respiratory risks increase with prolonged smoking exposure.
Causal relationship between tractography-based brain white matter structural connectome and risk of psychiatric disorders: A bidirectional Mendelian randomization study.
Lin Xuhui et al.
Psychiatry research. Neuroimaging • 2026
# Clinical Summary This study used genetic analysis to investigate whether differences in brain white matter connections causally influence the risk of nine psychiatric disorders including depression, schizophrenia, autism, and bipolar disorder. The researchers examined 206 different measures of brain connectivity to determine which structural brain changes might directly contribute to developing psychiatric conditions.
Randomised Controlled Trial Evidence on Medicinal Cannabis for Treatment of Mental Health and Substance Use Disorders: A Scoping Review.
Cooling Sophie et al.
Clinical drug investigation • 2026
This scoping review examined randomized controlled trials testing medicinal cannabis for mental health and substance use disorders, finding that evidence remains inconclusive due to variations in how studies were designed and conducted. While cannabis shows promise for some conditions like multiple sclerosis and epilepsy, its safety and effectiveness for treating mental health conditions are still controversial and require further rigorous research.
Psychosocial challenges and substance use among suicidal autistic individuals on social media: LLM-assisted keyword generation with human-in-the-loop refinement.
Sazzed Salim
International journal of medical informatics • 2026
# Clinical Summary This study examined psychosocial challenges and substance use patterns among autistic individuals expressing suicidal thoughts on social media using AI-assisted analysis. The research highlights the need for autism-specific suicide prevention strategies that address the particular mental health struggles and substance use issues present in online autism communities.
Tobacco and cannabis co-use by route of administration in the United States, 2022/2023.
Gibson Laurel P et al.
Addictive behaviors • 2026
# Clinical Summary This study found that co-use of tobacco and cannabis among US youth and adults has become increasingly common, with different methods of use (smoking, vaping, and oral products) showing distinct patterns. The research provides updated national estimates showing which age groups and populations are most likely to use both substances together through various routes of administration.
Chronic Insomnia and Excess Cannabis Ingestion in an Older Adult-A Clinical Report of Complex Geriatric Care.
Fraunberger Erik et al.
Journal of the American Geriatrics Society • 2026
# Clinical Summary An older adult with chronic insomnia was using excessive cannabis, which created multiple health risks including cognitive impacts, fall risks, and dangerous medication interactions. Careful assessment of cannabis use in older patients is essential because it can worsen the very problems it is being used to treat and complicate other medical conditions.
Socioeconomic outcomes following outpatient treatment for alcohol, cannabis, and gambling disorder in Greenland: Changes in income, employment, and welfare utilization.
Flyger Julie et al.
Journal of substance use and addiction treatment • 2026
# Clinical Summary This study of 1,157 Greenlandic adults found that outpatient treatment for alcohol, cannabis, and gambling disorders was associated with improvements in employment status and reduced welfare dependence during the year following treatment completion. Participants showed measurable increases in annual income and decreased reliance on social assistance benefits in the year after treatment ended compared to the year before starting treatment.
Determining the impact of cannabis use on tobacco cessation: Results from a prospective non-randomized tobacco treatment trial.
McClure Erin A et al.
Addiction (Abingdon, England) • 2026
# Clinical Summary This prospective study found that cannabis use during tobacco cessation treatment negatively impacts success rates in quitting tobacco. The findings suggest that co-users of tobacco and cannabis may require modified treatment approaches or additional support strategies to achieve tobacco abstinence.
Intersecting marginalized identities, multiple discrimination, depressive symptoms, and cannabis use among U.S. young adults, 2021-2024.
Pang Yuk C et al.
Journal of ethnicity in substance abuse • 2026
# Clinical Summary This study found that young adults with multiple marginalized identities (based on race/ethnicity, gender, and sexual orientation) experience higher rates of discrimination across multiple domains, which is associated with increased depressive symptoms and cannabis use. The research demonstrates that experiencing discrimination in more than one area of identity significantly predicts worse mental health outcomes and substance use patterns among young adults aged 19-30.
Racism and Cannabis-Related Problems Among Hispanic/Latine Adults: The Role of Negative Emotions in Responses to Experiencing Racism.
Buckner Julia D et al.
Substance use & misuse • 2026
This study found that Hispanic/Latine adults who frequently experienced racism had higher rates of cannabis-related problems, with negative emotions directly caused by racism being a key mechanism driving this relationship. The findings suggest that racism-related stress and emotional responses, rather than general anxiety or depression, are what primarily link racial discrimination experiences to cannabis use problems in this population.
Cannabis Use in Older Individuals May Be an Important and Under-Recognized Risk Factor for Motor Vehicle Crashes.
Pearlson Godfrey D et al.
Cannabis and cannabinoid research • 2026
# Clinical Summary Older adults (age 65+) who use cannabis face increased risk of motor vehicle crashes, particularly because THC impairs the cognitive and motor skills needed for safe driving, and this risk is compounded by age-related declines in driving ability. Healthcare providers should recognize cannabis use as a potentially overlooked danger factor when older patients report driving, especially those with mild cognitive impairment or early dementia.
Gastroduodenal Disorders.
Törnblom Hans et al.
Gastroenterology • 2026
# Clinical Summary Gastroduodenal symptoms are organized into five main disorder categories, including functional dyspepsia (which presents as either meal-related fullness and early satiation or epigastric pain and burning), nausea and vomiting disorders (encompassing chronic syndromes, cyclic patterns, and cannabinoid-related hyperemesis), and excessive belching disorders. This classification system helps clinicians systematically evaluate and categorize upper gastroint
Managing Cannabinoid Hyperemesis Syndrome.
Rech Megan A et al.
Annals of emergency medicine • 2026
Just the Facts: cannabinoid hyperemesis syndrome.
Lang Eddy et al.
CJEM • 2026
Cannabis Use Patterns and Blood Profiles in Adolescent Cannabinoid Hyperemesis Syndrome.
Bloom Joshua et al.
Pediatric emergency care • 2026
I don’t have access to the full abstract or study results, as the provided text cuts off before the methods section is completed and no findings or results are presented. To provide an accurate 2-sentence clinical summary of the key findings, I would need you to share the complete abstract including the Results and Conclusions sections.
The dual roles of natural cannabidiol in combating oxidative stress and inflammation: A potential intestinal guardian.
Lv Biguang et al.
Redox biology • 2026
# Clinical Summary Cannabidiol (CBD) is a non-psychoactive compound from cannabis that shows promise in protecting the intestines by reducing oxidative stress and inflammation, two major factors that damage the gut lining and drive diseases like inflammatory bowel disease and colorectal cancer. Research suggests CBD works through antioxidant and anti-inflammatory mechanisms that help maintain intestinal barrier function and may prevent disease progression in gastrointestinal disorders.
State of the Art Review: Thiazide Diuretics Exploit the Endocannabinoid System via NAPE-PLD.
Garau Gianpiero
American journal of hypertension • 2026
Thiazide diuretics may lower blood pressure by activating the endocannabinoid system through NAPE-PLD, an enzyme that produces signaling molecules involved in vascular regulation. While cannabinoid receptor agonists show potential for treating hypertension, CB1 agonists carry significant risks including heart problems and kidney damage, making safer therapeutic approaches necessary for clinical use.
Digest generated March 16, 2026 at 08:05 PM