Overview
A study published in the Journal of Ethnopharmacology found that 10 non-psychotropic phytocannabinoids—particularly CBDV and CBG—demonstrated meaningful anti-inflammatory effects. Researchers from the University of Chemistry and Technology and the Czech Academy of Sciences found that CBDV significantly reduced IL-6 and TNF-α production and inhibited NF-κB activation. Critically, combinations of cannabinoids with plant-derived matrices produced synergistic effects—mixtures containing CBG or CBN were among the most potent. This supports the entourage effect hypothesis and highlights the therapeutic potential of minor cannabinoids.
Clinical Perspective
💊 MINOR CANNABINOIDS: MAJOR MEDICINE
A new study in the Journal of Ethnopharmacology demonstrates what plant medicine practitioners have long suspected: the entourage effect is real.
💊 10 non-psychotropic phytocannabinoids tested
🔹 ALL demonstrated anti-inflammatory effects
💊 CBDV: reduced IL-6, TNF-α, inhibited NF-κB activation
🌿 CBG + plant matrices = most potent combinations
💊 Acidic cannabinoid forms showed high antioxidant capacity
🔹 Synergistic effects stronger than individual compounds
Researchers from Czech Republic’s University of Chemistry and Technology and Academy of Sciences found that combining cannabinoids with natural plant fractions amplifies therapeutic potential.
This is the science that justifies preserving access to full-spectrum hemp products.
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