Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies
Clinicians should consider the varying levels of evidence regarding the efficacy and safety of cannabis and cannabinoids when making treatment decisions.
Cross-disorder GWAS meta-analysis of endocannabinoid DNA variations in major depressive disorder, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, and schizophrenia
This large-scale genetic meta-analysis provides robust evidence that the endocannabinoid system-particularly diacylglycerol lipase alpha (DAGLA)-serves as.
Video gaming and cannabis use: A scoping review
Clinicians should be aware of the potential relationship between video gaming and cannabis use among adolescents and young adults.
A Systematic Review of the Clinical Effects of Cannabis and Cannabinoids in Posttraumatic Stress Disorder Symptoms and Symptom Clusters
While cannabinoids may offer targeted relief for specific PTSD symptoms like nightmares and sleep disturbances (Cluster B and E).
The CB1 receptor as a convergence hub linking stress, sleep and appetite regulation: An integrative neurobiological model
The CB1 receptor as a convergence hub linking stress, sleep and appetite regulation: An integrative neurobiological model
Cannabinoid-based interventions for behavioral outcomes in children and adolescents with autism spectrum disorder: A systematic review of safety and effectiveness
While observational studies and one RCT suggest modest behavioral and social communication benefits from full-spectrum.
Cannabis and cannabidiol for postoperative pain management in orthopedic surgery: a scoping review
Current clinical evidence regarding the use of cannabinoids for postoperative pain in orthopedic surgery remains inconclusive due to significant trial.
Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial
Clinicians should be aware of the complex relationship between cannabis use and alcohol consumption.
Acute behavioural effects of low-dose cannabidiol: A randomised crossover trial in healthy volunteers
Clinicians should be cautious when recommending low-dose CBD products, as the evidence for their effects is still inconclusive.
A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Study
In this prospective, triple-blind, placebo-controlled trial, oral dronabinol (2.5 mg twice daily) failed to reduce opioid consumption or improve secondary.
