Condition ARCHIVE

Post-traumatic stress disorders: research and patient questions

Physician-reviewed summaries of published studies and answered patient questions that name Post-traumatic stress disorders. Every study linked here carries a PubMed identifier that was checked against PubMed.

Verified NIH / PubMed 100% matched to primary citations

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All Research Studies 4 Pain 14 Adverse events 14 Cannabis use 13 Anxiety 12 Chronic pain 11 Cancer 9 Pharmacokinetics 8 Postoperative pain 7 Sleep 7 Inflammation 6

Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial

Fear Post-traumatic stress disorders Amidohydrolases Endocannabinoids

This study looked at adults with post-traumatic stress disorder, a condition that can follow frightening events. Participants took either a experimental medicine or a dummy pill for four weeks, then had brain scans while doing a task involving emotional images and words.

Key Findings: It made no measurable difference to the brain scans. The medicine did raise a natural calming chemical in the blood, but the brain activity patterns looked the same in both groups.

Assessment of clinical outcomes in patients with post-traumatic stress disorder: analysis from the UK Medical Cannabis Registry

Anxiety Post-traumatic stress disorders Hallucinogens Medical cannabis

Further research is needed to establish the efficacy and safety of cannabis-based medicinal products in treating PTSD, as current evidence is limited.

Key Findings: Investigation of health-related quality of life changes in PTSD patients. Assessment of adverse events associated with CBMPs.

A Systematic Review of the Clinical Effects of Cannabis and Cannabinoids in Posttraumatic Stress Disorder Symptoms and Symptom Clusters

Marijuana abuse Post-traumatic stress disorders Cannabinoids Cannabis

While cannabinoids may offer targeted relief for specific PTSD symptoms like nightmares and sleep disturbances (Cluster B and E), current evidence does not support major global improvements in overall PTSD severity. Furthermore, frequent use or concurrent Cannabis Use Disorder (CUD) is strongly linked to worsening symptom trajectories, increased suicidality, and aggressive behaviors, necessitating careful screening and caution in clinical practice.

Key Findings: Out of 10 non-CUD studies examining overall PTSD symptoms, 5 suggested benefits and 5 suggested no effect or worsening. All 3 studies evaluating patients with comorbid PTSD and CUD reported risks for worsening of overall symptoms and slower...

“Does medical cannabis actually treat PTSD? | CED Clinic”

Marijuana abuse Post-traumatic stress disorders

Clinical research indicates that cannabinoids do not "cure" PTSD or reliably lower total PTSD severity scores across the board, but they can offer targeted temporary relief for specific symptom clusters like traumatic nightmares, sleep disruption, and...

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