Pain, Depression, and Functional Outcomes Among Older Adults Who Use Cannabis or Opioid Analgesics for Chronic Pain Conditions
This study looked at older adults with chronic pain who use cannabis or opioids. It tracked their pain levels, ability to function, and feelings of depression over time. The study found that cannabis users had more pain and felt more depressed, while opioid users had more pain but no change in depression or function.
Fentanyl Detection in Biological Samples From Individuals Reporting Synthetic Cannabinoid Use in São Paulo, Brazil
This study looked at people in São Paulo, Brazil, who said they had recently used a lab-made cannabis-like product, sometimes called spice or K2. Researchers tested a saliva sample from each person and compared the results with what the people said they had taken.
Heart rate response to cannabis in active older adults
This study looked at older adults who were starting to use cannabis edible products for sleep, pain, or mood problems. Researchers checked their resting heart rate before and two hours after they ate a product, and measured THC in their blood.
Tai Chi exercise of short duration alters circulating oxylipins in postmenopausal women: a pilot study
Sixteen women past menopause, who had not practiced a mind-body exercise recently, took part in this small study. Each completed four gentle Tai Chi sessions over about ten days, and their blood was tested before and after.
Cannabis Use Disorder and Postoperative Pain: Elevated Analgesic Requirements After Surgical Repair of Hand Fractures
Researchers studied medical records to compare pain medication use after hand fracture surgery between patients diagnosed with problematic cannabis habits and those without such a diagnosis. They matched patients based on age, sex, overall health, and injury severity to ensure a fair comparison of their recovery periods.
Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives
Researchers investigated what cancer survivors think about using cannabis and whether they worry about being judged for it. They interviewed and surveyed adults who had finished cancer treatments, comparing those who used cannabis to manage symptoms with those who did not.
Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS
Researchers studied whether patients with digestive system cancers who received prescriptions for Food and Drug Administration-approved cannabis medications during early chemotherapy reduced their reliance on opioid pain medications. They analyzed electronic health records from a large national network of health systems covering more than one hundred forty thousand patients over a multi-year period.
Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain
Researchers followed adults living with long-term lower back pain who chose to use edible cannabis products from legal stores over a two-week period. Participants filled out daily questionnaires about their pain levels, whether they consumed their cannabis product, how many times they used it, and the estimated amounts of plant compounds they took. The goal was to see how different mixtures of major cannabis plant compounds related to daily and short-term changes in pain.
Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study
This study followed 52 people with long-lasting nerve pain caused by diabetes who had not improved with standard medicines. Each person was given medical cannabis breathed in through a vaporizer or smoked, with the amount adjusted to their pain, and they were checked once a year for five years.
Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
This study looked at young people aged 8 to 17 who had depression, and compared them with young people without depression. Researchers measured two chemicals that are stored in hair over several months: a stress hormone called cortisol and a body chemical called anandamide. They also tracked the young people with depression over about nine months, while some of them took fish-oil capsules or a dummy pill.
