Phospholipid-Based Delivery System Optimizes the Solubility and Systemic Exposure of Palmitoylethanolamide and Supports Clinical Benefits in Chronic Neuropathic Low Back Pain
Plain-Language Summary:
A group of adults with long-lasting lower back pain that has a nerve-related component took part in a study. They were given a daily supplement made from a natural body fat molecule, packaged in a form designed to be absorbed better, or a dummy pill, for eight weeks alongside their usual care.
Key Findings:
The supplement helped. People who took it reported less pain, less trouble with daily activities, better sleep and a better quality of life than people who took the dummy pill, and many of them needed fewer pain medicines....
Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
Plain-Language Summary:
This study followed 241 adults with long-standing lower back pain that had not improved with usual treatments such as prescription painkillers, nerve medicines, antidepressants, anti-inflammatory tablets and physiotherapy. Each person started a medical cannabis treatment that was mostly smoked, and their progress was tracked once a year for five years.
Key Findings:
The study found that pain and daily function improved over the five years, and many people stopped taking their stronger prescription medicines. The study had no comparison group that did not receive cannabis, so it cannot prove the...
