Daily Research & Patient Questions
Table of Contents
- Daily Research & Patient Literature Board
- Literature Presentation Boards
- Cannabis Use Disorder and Postoperative Pain: Elevated Analgesic Requirements After Surgical Repair of Hand Fractures
- Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives
- Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS
- Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain
- Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study
- Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
- Cannabis, Pain, and Complications: A Prospective Analysis of Cannabis Use, Opiate Consumption, and Postoperative Outcomes following Cancer-Related Abdominal Surgery
- Changes in Cross-Sectional Associations Between Cannabis Use and Anxiety, Depression, and Suicidality in a Nationally Representative Sample of Canadians From 2012 to 2022: Évolution des relations transversales entre la consommation de cannabis et la dépression, l’anxiété et les idées suicidaires au sein d’un échantillon représentatif de Canadiens à l’échelle nationale, de 2012 à 2022
- Blowing Minds: A cross-cultural, longitudinal investigation to unravel the highs and lows of recreational and medicinal cannabis users
- Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts
- Ask Dr. Caplan a Question & Explore Answered Patient Archive
- Have a Question?
- Daily Answered Q&A Corkboard Stream
- “Does ingesting cannabis nano emulsions effect nitric oxide production”
- “I have PTSD and keep hearing that cannabis is a lifesaver for trauma. Does medical cannabis actually treat PTSD, or does the clinical research show it can make symptoms worse?”
- “Why does a low dose of cannabis help my anxiety and pain, but if I take slightly more it suddenly makes my anxiety worse and my heart race? Why does it flip like that?”
- “Is THCV truly an appetite suppressant? Why isn't it all over the market?”
- “I have a root canal coming up and someone suggested taking CBD beforehand to calm my nerves and help with the pain after. Does that work?”
- “I am starting chemotherapy next month and I am already nauseous just thinking about it. Does cannabis actually help with that, or is it wishful thinking?”
- “Does medical cannabis help with cancer pain and the general awfulness of advanced cancer?”
- “Is there any evidence for cannabis helping tics in Tourette syndrome? My son has tried a lot of medications without much luck.”
- “My father has Parkinson's and keeps reading that cannabis helps with tremor. Is there anything behind that?”
- How we cite research
- Thank you for your question
Daily Research & Patient Literature Board
New research, explained two ways: a plain-English summary and a deeper scientific read.
Literature Presentation Boards
Browse recent studies from the clinical literature.
Cannabis Use Disorder and Postoperative Pain: Elevated Analgesic Requirements After Surgical Repair of Hand Fractures
Researchers studied medical records to compare pain medication use after hand fracture surgery between patients diagnosed with problematic cannabis habits and those without such a diagnosis.
Read the findings and why they matter →Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives
Researchers investigated what cancer survivors think about using cannabis and whether they worry about being judged for it. They interviewed and surveyed adults who had finished cancer treatments, comparing those who used cannabis to manage symptoms with those who did not.
The results showed that most people held positive attitudes toward cannabis and did not feel personally judged for using it. However, a few patients still chose to hide their cannabis use from their doctors out of caution, while many expressed deep concerns and shame regarding prescription pain medications.
This study highlights that while social judgment around cannabis is less common than expected among cancer survivors, communication barriers between patients and doctors still exist. It demonstrates that fears surrounding prescription pain medications heavily influence why patients seek out alternative plant-based options. Clinicians should take note that patients benefit greatly from safe, open conversations about all symptom relief methods without fear of judgment.
Purpose This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis. Methods This study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n=23) who use (n=10) and do not use (n=13) cannabis to manage symptoms. CS were recruited from a multi-site observational study in the Northeast U.S. region that assesses cannabis use among oncology patients. Results A total of 23 CS participated in this study. In general, this sample appeared to have positive attitudes towards cannabis, as indicated by quantitative results, and most CS felt accepting or neutral about other CS using cannabis, irrespective of whether they used or not. Most CS did not indicate experiences of stigma for cannabis use, did not feel judged by their medical providers, and indicated a feeling of empowerment to do whatever was needed to feel better. However, several CS reported intentional nondisclosure to their providers. Many CS discussed the presence of opioid-related stigma, both perceived from society and internalized, which appeared to play an important role in their symptom-management decision-making. Conclusions Findings from this study suggest that while cannabis stigma may not be commonplace for CS, some do experience it. Further, opioid stigma appears to be perceived and intertwined in the decision-making processes for CS in this sample.
Does Cannabinoid Use Reduce Opioid Utilization Among Patients with Gastrointestinal Cancer? Evidence from Epic COSMOS
Researchers studied whether patients with digestive system cancers who received prescriptions for Food and Drug Administration-approved cannabis medications during early chemotherapy reduced their reliance on opioid pain medications.
Read the findings and why they matter →Lower Pain Intensity Is Associated with the Use of Recreational Edible Cannabis Products Containing Delta-9-Tetrahydrocannabinol: A Secondary Analysis in Adults Self-Managing Their Chronic Low Back Pain
Researchers followed adults living with long-term lower back pain who chose to use edible cannabis products from legal stores over a two-week period.
Read the findings and why they matter →Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study
This study followed 52 people with long-lasting nerve pain caused by diabetes who had not improved with standard medicines.
Read the findings and why they matter →Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
This study looked at young people aged 8 to 17 who had depression, and compared them with young people without depression.
Read the findings and why they matter →Cannabis, Pain, and Complications: A Prospective Analysis of Cannabis Use, Opiate Consumption, and Postoperative Outcomes following Cancer-Related Abdominal Surgery
Researchers followed adults undergoing major abdominal operations for cancer to see how regular use of cannabis affects pain levels, pain medication needs, and recovery complications.
Read the findings and why they matter →Changes in Cross-Sectional Associations Between Cannabis Use and Anxiety, Depression, and Suicidality in a Nationally Representative Sample of Canadians From 2012 to 2022: Évolution des relations transversales entre la consommation de cannabis et la dépression, l’anxiété et les idées suicidaires au sein d’un échantillon représentatif de Canadiens à l’échelle nationale, de 2012 à 2022
Researchers analyzed two large national health surveys from Canada conducted ten years apart to understand how cannabis use relates to anxiety, depression, and thoughts of suicide over time.
Read the findings and why they matter →Blowing Minds: A cross-cultural, longitudinal investigation to unravel the highs and lows of recreational and medicinal cannabis users
The Blowing Minds protocol establishes a robust framework to evaluate the complex, real-world interactions between cannabis use (medicinal vs. recreational), affect, cognition, and legal context using ecological momentary assessment.
Read the findings and why they matter →Cannabis and tobacco co-use predicts psychosis in clinical high risk cohorts
The study looked at individuals at high risk for psychosis and healthy controls to understand the effects of cannabis and tobacco use.
Read the findings and why they matter →Ask Dr. Caplan a Question & Explore Answered Patient Archive
Submit an anonymous question for physician review or browse verified scientific answers on our daily corkboard.
Have a Question?
Submit your question below. Selected questions are answered after physician review.
Daily Answered Q&A Corkboard Stream
Patient questions, answered by a physician.
“Does ingesting cannabis nano emulsions effect nitric oxide production”
We do not currently have human studies showing that cannabis nanoemulsions directly increase or decrease nitric oxide production.
Clinical research indicates that cannabinoids do not "cure" PTSD or reliably lower total PTSD severity scores across the board, but they can offer targeted temporary relief for specific symptom clusters like traumatic nightmares, sleep disruption, and intense hyperarousal.
Cannabis compounds often produce what pharmacologists call a "biphasic effect," meaning low doses and higher doses can produce opposite reactions in the body.
“Is THCV truly an appetite suppressant? Why isn't it all over the market?”
While early research suggests tetrahydrocannabivarin (THCV) may reduce appetite in some contexts, the evidence is not yet strong enough to call it a reliable or proven weight-loss tool.
“I have a root canal coming up and someone suggested taking CBD beforehand to calm my nerves and help with the pain after. Does that work?”
The one trial that tested exactly this did not find a benefit.
“I am starting chemotherapy next month and I am already nauseous just thinking about it. Does cannabis actually help with that, or is it wishful thinking?”
For nausea that persists despite standard anti-sickness medicine, there is real evidence it helps.
“Does medical cannabis help with cancer pain and the general awfulness of advanced cancer?”
This is a very tricky question - with answers that keep changing with different papers and patient reports.
“Is there any evidence for cannabis helping tics in Tourette syndrome? My son has tried a lot of medications without much luck.”
There is, from a small but carefully designed trial.
“My father has Parkinson's and keeps reading that cannabis helps with tremor. Is there anything behind that?”
For now, less than the enthusiasm suggests.
How we cite research
Every study linked on this page is checked against PubMed so the link goes to the paper it names. If a study can no longer be verified, any answer relying on it is taken down until a physician reviews it again. Software can confirm that a citation is real. It cannot confirm that a study supports what we wrote. That judgment belongs to our reviewing physicians.
Thank you for your question
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