Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
This study followed 241 adults with long-standing lower back pain that had not improved with usual treatments such as prescription painkillers, nerve medicines, antidepressants, anti-inflammatory tablets and physiotherapy. Each person started a medical cannabis treatment that was mostly smoked, and their progress was tracked once a year for five years.
Investigating the effects of cannabinoids for the reduction of inflammation and sickle cell disease pain (CRISP); A protocol for a randomized double-blind placebo-controlled study
This is a plan for a study of adults with sickle cell disease who have long-lasting pain. Participants are randomly assigned to take a prescription synthetic form of the main active ingredient in cannabis (called dronabinol) or an inactive pill for eight weeks, and neither they nor the researchers know which one they receive.
Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier function in adults with obesity: A randomized, double-blind, placebo-controlled trial
Researchers in Australia studied 57 adults with obesity. Half took a supplement containing a natural fat-derived compound, and half took a harmless filler capsule, for three months, with neither the participants nor the researchers knowing who got which.
