Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ 9 ‐Tetrahydrocannabinol Without Improving Its Analgesic Properties
Clinicians should be aware that while CBD may increase the psychoactive effects of THC, it does not enhance its analgesic properties.
Acute and Extended Anxiolytic Effects of Cannabidiol in Cannabis Flower: A Quasi-Experimental ad libitum Use Study
Consider recommending CBD-dominant cannabis for patients with anxiety symptoms, as it may provide greater relief compared to THC-dominant options.
A Preliminary Pharmacokinetic Comparison of Δ-9 Tetrahydrocannabinol and Cannabidiol Extract Versus Oromucosal Spray in Healthy Men and Women
Clinicians should consider the route of administration when prescribing THC:CBD formulations, as bioavailability may vary significantly between methods.
A randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report
Clinicians should be aware of the potential driving impairments associated with cannabis use and advise patients accordingly.
A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer’s Disease
Consider dronabinol as a potential treatment option for managing agitation in Alzheimer's disease.
Cannabis dosing and administration for sleep: a systematic review
Integrative physicians should consider cannabis as a potential treatment for sleep disorders, while paying close attention to dosing to maximize benefits.
Acute Effects of Oral Cannabinoids on Sleep and High‐Density EEG in Insomnia: A Pilot Randomised Controlled Trial
Consider the use of oral cannabinoids as a potential treatment option for patients with insomnia.
Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals
In healthy men, acute administration of the cannabinoid receptor agonist nabilone enhanced peripheral insulin sensitivity while reducing fasting.
A Pilot Randomized Placebo-Controlled Crossover Trial of Medicinal Cannabis in Adolescents with Tourette Syndrome
This pilot study indicates that medicinal cannabis may be a feasible treatment option for adolescents with Tourette Syndrome.
Adverse events caused by cannabinoids in middle aged and older adults for all indications: a meta-analysis of incidence rate difference
Clinicians should be cautious when prescribing cannabinoid-based medicines to older adults due to the limited data on adverse events.
