Cannabis for sleep in older adults: use has outpaced the science
This is a review article about older adults, meaning people aged 50 and up, who use cannabis to help them sleep. The authors looked at what research already exists and what is still missing. They did not run a new study with patients.
Results of an Exploratory Crossover Pharmacokinetic Study Evaluating a Natural Hemp Extract-Based Cosmetic Product: Comparison of Topical and Oral Routes of Administration
Twenty healthy adults took a hemp-derived oil product that contains a substance called cannabidiol, either by mouth or rubbed onto the skin, at different times. Blood was drawn over the following day to see how much of the substance entered the body by each route.
Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants
The co-administration of MDMA with LSD may prolong the subjective effects of LSD without altering their quality, which could be relevant in therapeutic settings. Caution is advised due to potential increases in blood pressure and heart rate.
Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial
Clinicians should be cautious when prescribing CBD-dominant cannabis products, as they may produce stronger adverse effects than expected. Understanding cannabinoid interactions is crucial for safe therapeutic use.
Enhancing cannabinoid bioavailability: a crossover study comparing a novel self-nanoemulsifying drug delivery system and a commercial oil-based formulation
It helped: The new powder form led to higher levels of cannabinoids in the blood and reached those peaks much faster than standard oil drops, while both versions were well tolerated.
Regulating for Safety: Cannabidiol Dose in Food: A Review
While purified CBD is generally well-tolerated in clinical trials, the widespread availability of unregulated CBD-infused foods presents safety risks due to unpredictable dosing, lack of extract standardization, and pronounced increases in bioavailability when consumed with dietary fats. Integrative clinicians should counsel patients on the variability and lack of federal safety oversight in commercial CBD food products, keeping potential drug-drug interactions and elevated liver enzyme risks in mind.
