Research studies, summarized and reviewed by Dr. Benjamin Caplan, MD¹ (Page 3)

This study looked at whether a nightly supplement combining a natural fatty compound called palmitoylethanolamide with the sleep hormone melatonin could help people who get occasional migraines. Sixty adults were split evenly into two groups, and neither the participants nor the researchers knew who was getting the real supplement or the dummy pill.

The study looked at whether a pharmaceutical version of cannabidiol (CBD) could help patients with heart inflammation. Researchers used a specific type of imaging called cardiac magnetic resonance (CMR) to see if CBD improved the condition of the heart.

Thirty young adults who sometimes use cannabidiol, a non-intoxicating part of the cannabis plant, took part in this study. Each person breathed in vapor on three separate days: one with no cannabidiol, one with a low amount, and one with a higher amount, without knowing which was which. Researchers then checked many aspects of their eyesight.

This report describes one older man who needed a procedure to clear a blocked bile duct. The doctors had to guide a tube through a stomach that was folded into an unusual shape.

This study looked at how cannabidiol (CBD), a compound from cannabis plants, affects athletes during endurance exercise. Researchers compared how CBD and a placebo affected athletes' physical responses and how they felt during exercise. The study aimed to see if CBD could help with recovery or performance.

Researchers in Brazil studied adult patients with painful knee osteoarthritis to see if a daily plant extract oil rich in cannabidiol helped reduce joint pain and improve daily living. Participants took either the cannabis oil or an inactive oil twice a day for two months while keeping their regular doctor-prescribed medications.

Older adults with severe shaking movements of the hands received daily oral capsules containing pharmaceutical grade plant extracts of tetrahydrocannabinol and cannabidiol, compared against identical inactive placebo capsules in a crossover design.

Researchers investigated whether taking a common daily amount of hemp extract oil affects liver health and hormone levels in healthy adults. Over two hundred participants took either the study liquid or an inactive liquid twice daily for four weeks while having their blood tested regularly.

This study looked at adults who drink heavily and also use cannabis regularly. Each person came to the lab on three separate days and smoked either a cannabis cigarette with no active ingredient, a weaker cigarette, or a stronger cigarette, and rated how strongly they wanted alcohol before and after.

Sixty adults with long-lasting lower back pain that runs down into the leg were given a daily powdered supplement for four weeks. The supplement combined a fatty compound called palmitoylethanolamide with an extract from a flowering plant. Everyone knew they were taking it, and there was no comparison group receiving a dummy product.