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What a Target Trial Emulation Reveals About GLP-1 Safety in Patients With Opiate Use Disorder
This large target trial emulation evaluated GLP-1 safety in opioid use disorder using national claims data. Investigators found no increased risk across ten gastrointestinal, psychiatric, respiratory, and renal outcomes. The findings provide important…
Hair Shedding, Weight Loss, and GLP-1 Therapy: Separating Signal from Speculation
GLP-1 hair loss risk has become a growing concern as semaglutide and tirzepatide use expands. A large propensity-matched cohort study found significantly higher rates of nonscarring hair loss among users of both medications compared with metformin. The…
Cannabis Medicine in Family Practice: Evidence-Based Dosing Strategies from Endocannabinoid System Research
This article reviews evidence-based cannabis dosing strategies in family practice, emphasizing insights from endocannabinoid system research. Understanding these strategies helps clinicians optimize cannabis medicine use. Evidence-based cannabis dosing…
Why Higher THC Exposure Does Not Necessarily Mean Stronger THC Effects
THC blood levels vs effects is one of the most misunderstood concepts in cannabis medicine. A new study found that CBD increased THC exposure in the bloodstream after vaporized cannabis use. However, higher THC blood concentrations do not automatically…
THC and Alzheimer’s Agitation
THC for Alzheimer’s agitation is drawing attention after a randomized placebo-controlled dronabinol trial reported short-term reductions in agitation scores. The study is clinically meaningful because dementia-related agitation can be devastating for…
SAMHSA’s 2026 Clinical Guidance for Physicians and Patients on Cannabis Use Disorder
SAMHSA released a formal 2026 advisory instructing primary care physicians to evaluate cannabis use based on clinical signs of harm, not simply patient use. Dr. Caplan breaks down what this federal guidance actually says, where current diagnostic tools…
CBD Increases Food Intake in Controlled Human Trial
This clinical trial on CBD appetite regulation reveals that cannabidiol increases food intake in healthy adults. Despite lower ghrelin levels, participants consumed more calories, challenging previous assumptions. These findings highlight the complexity…
Cannabis Use in Pregnancy Linked to Child Behavioral Outcomes: A Study on Autism Spectrum Disorder
Peripregnancy cannabis exposure child development is associated with behavioral and developmental challenges in young children. This includes those with autism spectrum disorder symptoms and those without. The study highlights the importance of avoiding…
Cannabis Induced Psychosis: Systematic Review & Meta-Analysis on Schizophrenia Spectrum & Bipolar Disorder
Cannabis induced psychosis prevalence is significant in patients who later develop schizophrenia or bipolar disorder. This systematic review highlights the importance of monitoring and follow-up. Early identification may reduce progression risk to…
Cannabinoids for Anxiety & Tourette’s: Evidence from Systematic Reviews and Meta-Analyses in Cannabis Research
Systematic reviews and meta-analyses on cannabinoid formulations anxiety disorders reveal mixed evidence with some measurable effects. The quality and consistency of data vary across conditions and formulations. Clinicians should interpret these findings…