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Cannabis Medicine in Pediatrics: Evidence-Based Care and Emerging Research
Cannabinoids pediatric safety is critical in treating various medical conditions in children under 18. This review synthesizes evidence from hundreds of studies, focusing on safety and benefits. Clinicians should consult this continuously updated…
New Trial: 1:1 THC:CBD Oil Reduces Fibromyalgia Pain and Improves Sleep
A new double-blind, placebo-controlled trial found that cannabis oil with equal amounts of THC and CBD meaningfully reduced pain and improved sleep in fibromyalgia patients. The trial, conducted across three Australian research institutions, achieved a…
Medical Cannabis Evidence-Based Care: Endocannabinoid System Clinical Research and Cannabinoid Dosing in Family Medicine
Prenatal cannabis polysubstance use risks are significant in clinical care, especially when combined with alcohol and other substances. Understanding these patterns helps providers offer targeted counseling and referrals. This evidence-based approach…
Endocannabinoid System and Chronic Low Back Pain: A Phase 3 Trial on Cannabis Sativa Extracts
This phase 3 randomized placebo-controlled trial cannabis study evaluated the full-spectrum cannabis extract VER-01 for chronic low back pain. Results showed significant pain reduction compared to placebo over 12 weeks. The trial also assessed…
Cannabis & Psychosis Study
This cannabis psychosis study examined whether cannabis and tobacco co-use predicted psychosis conversion in people already considered clinically high risk. The paper identified a concerning subgroup signal involving heavy cannabis use and light tobacco…
A Synthetic Cannabinoid Did NOT Reduce Opioid Use After Knee Replacement Surgery
A new postoperative randomized trial found no significant opioid reduction from a synthetic cannabinoid after total knee arthroplasty. The findings challenge broad assumptions that cannabinoids reliably reduce opioid use in every pain setting. The study…
What the Latest Physiology Research Reveals About Cannabis Formulation and Diabetes Risk
A Journal of Physiology study from UC Riverside found that whole cannabis extract reversed the fat-to-pancreas signaling failure behind type 2 diabetes—while purified THC alone did not. The findings suggest the entourage effect may have direct…
A Placebo-Controlled Cannabis Trial for Migraine Just Produced Real Results
A new randomized placebo-controlled trial found vaporized THC-plus-CBD cannabis improved acute migraine symptoms compared with placebo. The study represents one of the strongest migraine cannabis trials published to date. Dr. Caplan explains why…
Endocannabinoid System Research: Cannabis Dosing Guidelines for Family Medicine Practitioners
Preventing alcohol and cannabis-impaired driving adolescents is critical for reducing risky behaviors. A brief web intervention added to driver education shows promise in shifting peer use perceptions. This approach supports safer driving decisions among…
Maternal Cannabis Exposure and Risk of ASD ADHD in Offspring: A Systematic Review of Endocannabinoid System Research
Maternal cannabis exposure risk ASD is linked to modest increases in autism and ADHD in offspring. Cannabis crosses the placental barrier affecting fetal brain development. This research highlights the importance of counseling against cannabis use during…