The First Cannabis Drug to Earn FDA Breakthrough Therapy Status for Pain`
The FDA has granted Breakthrough Therapy Designation to VER-01, a full-spectrum cannabis extract, after two Phase 3 RCTs showed significant pain reduction in patients with chronic low back pain. VER-01 outperformed opioids on both pain relief and…
SAMHSA’s 2026 Clinical Guidance for Physicians and Patients on Cannabis Use Disorder
SAMHSA released a formal 2026 advisory instructing primary care physicians to evaluate cannabis use based on clinical signs of harm, not simply patient use. Dr. Caplan breaks down what this federal guidance actually says, where current diagnostic tools…
CBD Increases Food Intake in Controlled Human Trial
This clinical trial on CBD appetite regulation reveals that cannabidiol increases food intake in healthy adults. Despite lower ghrelin levels, participants consumed more calories, challenging previous assumptions. These findings highlight the complexity…
Cannabis Use in Pregnancy Linked to Child Behavioral Outcomes: A Study on Autism Spectrum Disorder
Peripregnancy cannabis exposure child development is associated with behavioral and developmental challenges in young children. This includes those with autism spectrum disorder symptoms and those without. The study highlights the importance of avoiding…
Cannabis Induced Psychosis: Systematic Review & Meta-Analysis on Schizophrenia Spectrum & Bipolar Disorder
Cannabis induced psychosis prevalence is significant in patients who later develop schizophrenia or bipolar disorder. This systematic review highlights the importance of monitoring and follow-up. Early identification may reduce progression risk to…
Cannabinoids for Anxiety & Tourette’s: Evidence from Systematic Reviews and Meta-Analyses in Cannabis Research
Systematic reviews and meta-analyses on cannabinoid formulations anxiety disorders reveal mixed evidence with some measurable effects. The quality and consistency of data vary across conditions and formulations. Clinicians should interpret these findings…
Endocannabinoid System Research: Evidence-Based Cannabis Care for Older Adults with Pain, Sleep, and Mental Health Issues
Edible cannabis older adults prefer is often a balanced THC/CBD combination for managing pain, sleep, and mental health concerns. Understanding these preferences helps clinicians guide patients effectively. This research highlights pharmaceutical…
Cannabidiol Urine Concentrations in Athletes: Effects of Daily Use and Exercise
CBD urine concentrations in athletes climbed to detectable levels after just ten weeks of daily broad-spectrum supplement use at 150 mg per day. Exercise further amplified the effect, raising the risk that trace cannabinoids like CBG and CBDV would…
Cannabidiol Effects on Glutamate and Learning in Psychosis Prevention
Cannabidiol clinical trials psychosis research reveal that a single dose of CBD modulates hippocampal glutamate and prefrontal activation during memory tasks. This suggests CBD's potential to normalize disrupted brain circuitry in early psychosis. These…
Endocannabinoid System Clinical Research: Topical Cannabis Balm Efficacy in AIMSS Treatment
This study evaluates topical cannabis balm efficacy for managing AIMSS in breast cancer patients. The trial shows high tolerability and feasibility of cannabinoid balms. Results suggest potential benefits for aromatase inhibitor-related joint pain.