Association of Cannabis Use Disorder Versus Other Substance Use Disorders With Psychiatric Conditions: A Propensity-Matched Retrospective Cohort Analysis.

This item covers developments relevant to cannabis medicine and clinical practice. Clinicians monitoring evidence in this area should review the source material.

The authors compared the risk of mental disorders between patients with cannabis use disorder (CUD) and those with other substance use disorders (SUDs). The TriNetX Research Network was queried to identify patients with SUDs and no preceding mental disorders and compare 1) adult patients with CUD only versus those with other SUDs, 2) pediatric patients with CUD only versus those with other SUDs, and 3) adult patients with CUD plus another SUD versus those with comorbid noncannabis SUDs. Propensity score matching was performed on demographic characteristics and 24 risk factors or comorbidities. Subsequent diagnosis of schizophrenia and other common mental disorders was assessed. Compared to adults with other SUDs, those with noncomorbid CUD (N=345,903 for both cohorts) had a lower risk of schizophrenia (0.34% vs. 0.42%; relative risk [RR]=0.81, 95% CI=0.75, 0.88), depression (1.35% vs. 1.74%; RR=0.78, 95% CI=0.75, 0.81), and psychotic disorders (0.36% vs. 0.52%; RR=0.68, 95% CI=0.63, 0.

“This is a development worth tracking. The clinical implications will become clearer as more evidence accumulates.”

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