“The relationship between cannabis use disorder and psychiatric outcomes is nuanced and varies significantly by age and comorbidity.” — Ryan C. Nicholson, MD MPH
12-Month Patient-Reported Outcomes Among Urine Toxicology-Identified Substance Users After Elective Spine Surgery: A Prospective Longitudinal Cohort Study.
While prior studies have examined the role of opioids, alcohol, and marijuana use on early postoperative outcomes after elective spine surgery, longitudinal …
Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data.
Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric conditions, desp…
Reductions in cigarette and cannabis use during a randomized clinical trial for alcohol use disorder.
Recent clinical trial data shows that cannabis use during alcohol treatment follows a biphasic pattern, with early reductions followed by later increases. Understanding these polysubstance use patterns helps clinicians provide more comprehensive addiction treatment that addresses concurrent substance use beyond the primary substance of concern.
Endocannabinoid System and PTSD Alcohol Cannabis Use
Clinical Takeaway Clinical Takeaway: In trauma survivors, pre-existing insomnia symptoms significantly predict increased alcohol and cannabis use in the weeks following trauma exposure, suggesting sleep disturbance is a modifiable risk factor for...
Endocannabinoid System in HIV Smoking Cessation Care
Clinical Takeaway Clinical Takeaway Digital smoking cessation programs tailored specifically for people living with HIV can reach a traditionally underserved population and show comparable effectiveness to standard programs. These digital tools offer...
Endocannabinoid System in Trauma: Clinical Research Evidence
Clinical Takeaway Individuals who experience insomnia symptoms before trauma exposure show higher rates of alcohol and cannabis use in the months following the traumatic event. This relationship appears to be partially mediated...
Patient perspectives on non‑traumatic painful upper‑extremity conditions, co-occurring risky substance use, and an integrated web-based mind-body intervention addressing both conditions.
This study explored patient experiences with non-traumatic painful upper-extremity conditions (NPUCs) and co-occurring risky substance use and assessed persp…
Endocannabinoid System in PTSD and Substance Use Disorder
Clinical Takeaway Cannabis use does not significantly impair outcomes of evidence-based trauma-focused treatments for people with co-occurring PTSD and substance use disorders. Individuals using cannabis showed comparable treatment response rates to those...
Examining Impulsivity’s Effect on Enhancement Motives for Cannabis Use in College Students (2026)
✦ New CED Clinical Relevance #70Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. ⚒ Cannabis News | CED Clinic Young AdultsSubstance Use DisorderRisk AssessmentBehavioral HealthPrevention Why This MattersUnderstanding the relationship between impulsivity and...