Clinical Takeaway Systematic review and meta-analysis of randomized controlled trials found limited evidence supporting cannabinoids as a primary treatment for mental disorders or substance use disorders. Current data do not establish clear...
The association between major depressive disorder and cannabis use disorder: A meta-analysis and meta-regression analysis.
Major Depressive Disorder (MDD) and Cannabis Use Disorder (CUD) frequently co-occur, yet prevalence estimates vary widely across settings. This meta-analysis…
Health-related quality of life in patients receiving medicinal cannabis: systematic review and meta-analysis of primary research findings 2015-2025.
The global burden of chronic health conditions is significant. Medicinal cannabis (MC) is a legalised treatment option for patients with chronic health condi…
Cannabinoids for Mental Health: Large Review Finds Mostly Low-Quality Evidence With Few Clear Benefits
There is a crucial need for more high-quality research. Given the scarcity of evidence, the routine use of cannabinoids for the treatment of mental disorders and SUDs is currently rarely justified.
Comprehensive Review Reveals Cannabis Use Disorder Affects 10% of World’s 193 Million Cannabis Users
Cannabis use disorder occurs in approximately 1 in 10 regular users and as many as one-third of those who use daily, with persons with CUD having higher risks of poor mental health, psychoses and bronchitis.
Medical cannabis not effective as a mental health treatment, finds meta analysis
✦ New CED Clinical Relevance #75 Strong Clinical Relevance High-quality evidence with meaningful patient or clinical significance. ResearchMental HealthSafetyAnxiety Why This Matters Clinicians should be aware that this meta-analysis provides evidence against...
`Cannabinoid Clinical Trials: PTSD and Substance Use`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments. Cannabis use does not appear to undermine the effectiveness of evidence-based PTSD...
`Endocannabinoid System & PTSD Substance Use: Meta-Analysis`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who also use cannabis can still benefit meaningfully from trauma-focused treatments. Cannabis use does not appear to undermine the effectiveness of evidence-based...
`Cannabinoid Clinical Trials: Cannabis, PTSD & Substance Use`
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments. Cannabis use should not be used as a reason to withhold or...
Cannabinoids and PTSD: Clinical Research on Co-Occurring SUD
Clinical Takeaway People with PTSD and co-occurring substance use disorders who use cannabis can still benefit meaningfully from trauma-focused treatments. Clinicians should not withhold or delay evidence-based PTSD care based on a...