Cannabis Use Linked to Changes in Inflammatory Gene Expression in HIV-Positive Immune Cells, But Causal Claims Remain Premature

MDMs without treatment from PWH exhibited 83% higher NLRP3 mRNA expression compared to MDMs from PWoH. When treated with CBD and IL-1ฮฒ, a significant increase in both IL1b (3-fold, p<0.01) and IL18 (2-fold, p<0.01) expression was observed compared to vehicle, an unexpected finding that contradicts a simple anti-inflammatory interpretation.

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