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The Last Step of THC Metabolism: What Glucuronidation Explains About Drug Tests and Drug Interactions
THC glucuronidation is the phase II step that attaches a sugar to oxidized THC metabolites and makes them water soluble enough to excrete. It explains why urine testing detects a conjugated acid metabolite rather than THC, and why only about 2 to 3…
Two Molecules, Two Routes: How the Body Handles THC and CBD Differently
THC and CBD metabolism run through overlapping liver enzymes to entirely different products, with THC oxidized principally by CYP2C9 to an active metabolite and CBD handled mainly by CYP3A4 and CYP2C19 into a family of hydroxylated compounds. Their…
North Carolina Advisory Group Recommends Legalizing Marijuana for Adults
The North Carolina marijuana legalization advisory signals important policy shifts clinicians must monitor. This advisory highlights potential changes in cannabis access and clinical guidelines. Providers should prepare for new patient safety and…
Pilot Study on Cannabis-Induced Alterations in Platelet Function: Implications for Transfusion Medicine
This pilot study investigates cannabis-induced alterations in platelet function and their potential impact on transfusion medicine. Researchers examined platelet activation and mitochondrial function after exposure to cannabis extracts. The findings…
Cannabis Dosing After 70: A Safe and Predictable Approach
Cannabis dosing variability is a critical consideration for seniors over 70. This guide offers a conservative framework prioritizing safety and predictability. Personalized dosing plans help minimize risks like dizziness and sedation.
Op-Ed: The Essential Role of Pharmacists in Cannabis Care
Pharmacists cannabis care role is crucial for patient safety in cannabis therapy. Their involvement ensures professional drug interaction checks and standardized dosing advice. Integrating pharmacists into cannabis care fills a critical gap in medication…
Understanding Cannabis Interactions with Drugs and Clinical Considerations
Cannabis drug interactions clinical considerations are essential for safe use with medications. Cannabis compounds affect enzyme metabolism, altering drug levels. Understanding these interactions helps prevent adverse effects and ensures clinical safety.