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Full-Spectrum Cannabis Extract Shows Significant Pain Reduction in Chronic Neuropathic Pain

CED Clinical Relevance
#75 Strong Clinical Relevance
High-quality evidence with meaningful patient or clinical significance.
PainResearchTHCCBDNeurology
Why This Matters
If you live with chronic nerve pain, this study provides clinical evidence that full-spectrum cannabis extracts can deliver meaningful relief with fewer side effects than many conventional pain medications.
Clinical Summary

A clinical study found that a full-spectrum cannabis extract containing a balanced ratio of THC and CBD produced statistically significant reductions in chronic neuropathic pain compared to placebo. Patients reported meaningful improvements in pain intensity, sleep quality, and overall quality of life with minimal adverse effects. The full-spectrum formulation appeared to leverage the entourage effect, with multiple cannabinoids and terpenes working synergistically to provide analgesia superior to isolated compounds.

Dr. Caplan’s Take
“Full-spectrum cannabis for neuropathic pain is exactly the kind of evidence-based application that deserves regulatory protection, not the blanket prohibition the November ban threatens to impose.”
Clinical Perspective

A promising clinical finding: full-spectrum cannabis extracts with balanced THC:CBD ratios demonstrate statistically significant pain reduction in chronic neuropathic conditions. Beyond pain intensity, patients reported meaningful improvements in sleep architecture and functional capacity—suggesting the entourage effect may offer broader therapeutic benefits than isolated cannabinoids alone.