Targeting Mechanosensitive CB1 with Isoflavone Prodrugs to Reduce Atherosclerosis
Atherosclerotic endothelial dysfunction is a key factor in cardiovascular disease progression. Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs offers a novel approach to reduce vascular inflammation. This strategy may improve…
Management of Opioid Withdrawal Syndrome and Opioid Dependence Treatment
Opioid withdrawal management is critical in cases involving synthetic opioid contamination such as protonitazene. This case report highlights the need for adjusted buprenorphine dosing. Effective opioid dependence treatment requires awareness of these…
Cannabis-Based Spray Shown Feasible and Safe for Alzheimer’s Agitation in UK Care Homes
The nabiximols Alzheimer agitation trial demonstrated that administering this cannabis-based spray is feasible and safe for patients in UK care homes. Despite challenges, the study showed perfect adherence and no adverse drug reactions. These results…
Cannabis Medicines Cause Dose-Dependent Side Effects in Older Adults, Meta-Analysis Finds
Dose-dependent side effects cannabinoids cause include dizziness, dry mouth, and coordination difficulties in older adults. This 2024 meta-analysis highlights the importance of cautious dosing. Understanding these risks helps clinicians manage…
Older Adults Prescribed Cannabis in UK Show Self-Reported Well-Being Gains, But Study Design Cannot Confirm Treatment Caused Improvement
The older adults cannabis registry study from the UK shows self-reported well-being improvements after prescribed cannabis use. However, the study design lacks a control group, so treatment effects cannot be confirmed. These findings highlight the need…
A Geriatrics Cannabis Clinic Shows Feasibility—But Not Yet Effectiveness
This report highlights geriatric cannabis clinic feasibility in a medically complex older adult population. It reveals an average of 4.6 drug interactions per patient, emphasizing pharmacological risks. The study underscores the need for structured…
Cannabis Positive Drug Screen Linked to Higher Blood Clot Risk in Older Trauma Patients
Cannabis thromboembolic risk geriatric patients is a growing concern as THC positive drug screens show higher rates of blood clots in older trauma patients. This study highlights increased DVT and PE risks in this population. Understanding these risks is…
Cannabinoids Show Modest Promise for Cancer-Related Appetite Loss in Older Adults, But Evidence Remains Thin
Cannabinoid receptor type 1 activation plays a role in appetite regulation for older adults with cancer-related anorexia. Current evidence shows modest benefits but remains limited and inconclusive. Further research is needed to establish clinical…
Three Conference Abstracts Explore Cannabis, Social Isolation, and Dementia Care in Older Adults
Systematic studies of cannabinoid use in older adults are needed given its increasing prevalence. Three 2021 conference abstracts explore cannabis, social isolation, and dementia care. These early findings highlight research gaps and clinical…
Large Canadian Study Documents How Older Adults Use Medical Cannabis — But Cannot Prove It Works
A large Canadian study on medical cannabis older adults Canada reports that most seniors using CBD-rich oils perceive improvements in pain, sleep, and mood. However, the absence of a control group means these benefits cannot be conclusively attributed to…