Prevalence and Correlates of Past-year Kratom Use Among US Adults
This kratom epidemiology mental health survey examines the prevalence and correlates of past-year kratom use among US adults. Findings highlight higher use in populations with psychological distress and depression. The study provides critical baseline…
Nonswallowed Kratom-Derived Products: Unlawful Dietary Supplements That Endanger Public Health.
Kratom regulatory safety is critical as non-oral kratom products bypass FDA oversight and violate dietary supplement laws. These unlawful formulations may endanger public health due to unknown safety profiles. Clinicians should be aware of these risks…
GPR3 in Neuro-Metabolic-Immune-Reproductive Nexus: Potential Therapeutic Target
GPR3 neuro-metabolic immune nexus represents a promising therapeutic target for multisystem diseases. This receptor influences neurological, metabolic, immune, and reproductive functions. Understanding GPR3's role may guide future cannabinoid therapies.
Local Therapeutic Strategies for Neurocutaneous Dysesthesia: From Capsaicin to Cannabinoids
Local therapeutic strategies neurocutaneous dysesthesia focus on topical treatments such as capsaicin and cannabinoids to manage abnormal skin sensations. These approaches provide targeted relief with fewer systemic effects. This review highlights…
Anticancer Potential of Cannabidiol in Renal Cell Carcinoma: Serum Modulation and Preliminary Mechanistic Insights.
This study explores the anticancer potential cannabidiol renal cell carcinoma effects through serum modulation. Preliminary mechanistic insights provide a foundation for further research. The findings highlight the need for cautious interpretation in…
Advances in Targeting Amyloid Beta Aggregation and Neuroinflammation in Alzheimer’s
Amyloid beta aggregation Alzheimer's disease is a key pathological mechanism driving cognitive decline. This article reviews advances in targeting amyloid beta aggregation and neuroinflammation. Natural products like curcumin show potential but require…
Unraveling Lennox-Gastaut Syndrome: Molecular Pathogenesis and Therapeutic Strategies
Lennox-Gastaut syndrome treatment challenges arise from its complex network dysfunction and drug-resistant seizures. Precision medicine approaches targeting molecular pathways offer new hope. CBD has shown efficacy as adjunctive therapy for this severe…
Precision Prediction of PTSD Symptom Surges Using Machine Learning
Machine learning PTSD prediction offers a promising approach to forecast symptom surges using real-time daily data. This pilot study integrates supervised learning to enhance dynamic symptom tracking. The findings highlight potential for early…
Factors Associated with Disposable vs Non-Disposable E-Cigarette Use in Adults
Disposable electronic cigarette use has rapidly increased among adults in the U.S. and Israel. This study identifies key factors influencing preferences between disposable and non-disposable devices. Understanding these patterns is essential for…
Medical Cannabis in Older Adults: Promising Interest, Thin Evidence
Medical cannabis safety older adults is a critical concern due to limited evidence and unique risks in this population. Current studies mostly exclude adults over 60, leaving a gap in clinical guidance. Careful individualized decision-making is essential…