Relationship of Ethanol, Cannabinoids, Benzodiazepines, and Opioids to Serious Injuries from Falls in Adults Aged 55 and Older
The falls geriatric cannabis safety cohort study examines the role of ethanol, cannabinoids, benzodiazepines, and opioids in serious injuries from falls in adults aged 55 and older. This research provides objective toxicological data to better understand…
Medicinal Cannabis Prescription Before Psychiatric Admission: Audit Results
This study investigates medicinal cannabis psychiatric inpatient use through a retrospective observational audit. It highlights prescription patterns and safety concerns in psychiatric populations. The findings provide important baseline data for…
Substance Use in Supportive Oncology and Its Impact on Clinical Outcomes and Care
Substance use in supportive oncology significantly influences clinical outcomes and treatment adherence. This review highlights the impact of alcohol, tobacco, cannabis, and opioids on cancer care. Understanding substance use patterns is essential for…
Loss of dystrophin reduces CB1 receptor expression and endocannabinoid-dependent synaptic plasticity in the cerebellar cortex.
Dystrophin endocannabinoid system disruption reduces CB1 receptor expression in the cerebellar cortex. This affects endocannabinoid-dependent synaptic plasticity, relevant to Duchenne Muscular Dystrophy. Understanding this mechanism may inform future…
Phase 2 Open-Label INSPIRE Trial on Transdermal CBD Gel in 22q11.2 Deletion Syndrome
The INSPIRE trial investigates transdermal cannabidiol gel children with 22q11.2 deletion syndrome to assess safety and tolerability. This phase 2 open-label study provides preliminary data on CBD gel use in pediatric neurodevelopmental disorders.…
A qualitative study on cannabis use for harm reduction and pain among veterans enrolled in an SUD treatment program.
This qualitative study explores veterans cannabis harm reduction within SUD treatment programs. Veterans report cannabis use for managing chronic pain and related symptoms. The findings highlight cannabis as a therapeutic tool in complex addiction…
Inpatient Hospital Admissions for People with Obsessive-Compulsive Disorder (OCD). A Position Statement by the International College of Obsessive-Compulsive Spectrum Disorders.
Inpatient hospital admissions OCD are less common than for other mental disorders but essential for severe cases. This position statement outlines guidelines for hospitalization. It highlights the need for clear protocols in managing OCD patients during…
Can Cannabis Replace Opioids for Chronic Pain? What We Know and What Remains Uncertain
This 2025 narrative review explores cannabinoid analgesia mechanisms and their role in chronic pain management. It highlights biological plausibility and clinical evidence supporting cannabinoids for neuropathic and arthritis pain. However, significant…
CBD Shows Promise But Lacks Broad Regulatory Approval: A Sobering Review of the Evidence
The CBD pharmacology regulatory context reveals a narrow evidence base supporting broad approval. Most CBD products lack pharmaceutical-grade quality and regulatory endorsement. This 2024 review highlights the need for rigorous clinical trials and…
Cannabis Risks and Medical Benefits: What the Evidence Actually Shows
This 2024 review on cannabis risks and medical benefits synthesizes seven years of research, emphasizing the real risks of chronic high-THC cannabis use. It highlights the dose-dependent associations with cannabis use disorder and psychosis risk. The…