Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia
The study of cb1 receptor biased signaling schizophrenia reveals new therapeutic possibilities. This research highlights how selective modulation of CB1 receptors may benefit schizophrenia treatment. Understanding this mechanism is crucial for advancing…
Selective TRPV2 Antagonists Derived from Piperlongumine Inhibit Cancer Cell Migration and Metastasis
Selective TRPV2 antagonists are emerging as important tools in cancer metastasis and pain research. Derived from the natural product piperlongumine, these antagonists offer improved selectivity over cannabidiol. This research advances understanding of…
Real-world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2-q13.1 duplication and deletion syndromes: A multicenter study.
This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol epilepsy treatment in 22 patients with 15q11.2-q13.1 duplication and deletion syndromes. Results showed significant seizure reductions and improved…
Cannabis-Related Hospital Visits Linked to Elevated Self-Harm and Suicide Risk
Cannabis-related hospital contact is associated with a significantly increased risk of deliberate self-harm and suicide in Ontario. This large population-level study found a 5.4-fold increased risk of self-harm and a 9.2-fold increased risk of suicide…
Canadian Cannabis Legalization Linked to Tens of Thousands of Estimated Annual Deaths—But the Numbers Require Careful Scrutiny
Cannabis-associated health risks contribute to an estimated 28,000 to 30,000 premature deaths annually in Canada. These figures derive from population-attributable fraction modelling rather than direct causal attribution. Understanding…
Australia’s Medical Cannabis Regulation at Eight Years: Rapid Growth, Persistent Gaps
Australian medical cannabis regulation has seen rapid growth from 2016 to 2024, with prescriptions rising dramatically. Despite this, persistent gaps remain in cost, access, and prescriber education. This review highlights key challenges and lessons from…
Daily Cannabis Users Under 50 Have 40% Higher Odds of Heart Disease, National Survey Finds
Cannabis use heart disease risk is notably higher in daily users under 50, with a 40% increase in odds compared to non-users. This national survey reveals a dose-response relationship between cannabis use and heart disease. The findings underscore the…
Study Finds Cannabis Knowledge Gaps Among Thai Border Patients
A 2025 study reveals significant cannabis knowledge public health education gaps among patients near the Thai-Cambodian border. Over 60% could not identify safe uses or side effects of cannabis despite legalization. This highlights urgent needs for…
Most Medical Cannabis Users Also Use Recreationally, Pre-Legalization Canadian Study Finds
A large Canadian study reveals medical recreational cannabis overlap is common pre-legalization, with most medical users also consuming recreationally. This dual use pattern associates with higher psychiatric symptoms and more frequent cannabis use.…
Who Is Recommending Medical Cannabis—and What Are They Telling Patients?
A 2019 survey highlights medical cannabis clinical practice patterns among providers, showing wide variation in education and dosing. This study reveals a self-generated community standard without formal guidelines. Understanding these patterns is key to…